Objective: To approach the curative effect and safety of Diacerein combined with Duhuo Jisheng decoction in the treatment of knee osteoarthritis. Method: One hundred and twenty patients with knee osteoarthritis were selected

which were divided into Duhuo Jisheng decoction group (group A)

Diacerein group (group B) and combination group (group C) randomLy. Every group was handled with the appropriate treatment. One month was a course

and totally with observation and treatment of three month. The VAS score

WOMAC score

ESR and CRP were the indicators of clinical efficacy

and the comprehensive efficacy score was evaluated. Result: After the treatment for three months

the VAS score

WOMAC score

erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP) were improved significantly than before(P<0.01).The indicators of clinical efficacy in group C were better the group B and C(P<0.05)

the comprehensive efficacy score were also best(P<0.01)

and with a lower rate of adverse events(7.5%). Conclusion: Diacerein and Duhuo Jisheng decoction were effective drugs for treatment of the knee osteoarthritis; the clinical efficacy was more significant when combined together

and with no obvious adverse events. It is worth promoting.