Investigation of Dissolvability of Danhuang Gel Extract

LI Jun-song; CHEN Xin-min; CHEN Li-hua; PENG Wen-wen; LI Wen

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Investigation of Dissolvability of Danhuang Gel Extract

更新时间：2024-01-04

- Investigation of Dissolvability of Danhuang Gel Extract
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 37-39(2012)
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- Published：2012
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LI Jun-song, CHEN Xin-min, CHEN Li-hua, et al. Investigation of Dissolvability of Danhuang Gel Extract[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 37-39.
DOI：

LI Jun-song, CHEN Xin-min, CHEN Li-hua, et al. Investigation of Dissolvability of Danhuang Gel Extract[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 37-39. DOI：

摘要

目的: 考察丹黄凝胶提取物及其指标成分大黄酚和小檗碱在外用制剂常用溶媒中的溶解性

同时测定提取物中大黄酚和小檗碱的油水分配系数。方法: 运用沉淀法、指标成分溶解量法测定提取物及其主要活性成分大黄酚和小檗碱的溶解性

采用摇瓶法测定提取物中大黄酚和小檗碱的油水分配系数。结果: 丹黄凝胶提取物及大黄酚和小檗碱在丙二醇中溶解性最好

溶解度分别为8.25

60.17

353.01 mg ·L-1;提取物中大黄酚和小檗碱的油水分配系数受pH 影响较大。结论: 丙二醇和乙醇能较好地溶解提取物及其活性成分大黄酚和小檗碱;适宜pH 可使大黄酚和小檗碱具有一定的脂溶性和水溶性

有利于其透皮吸收。

Abstract

Objective: To investigate dissolvability of Danhuang gel extract and its active components (chrysophanol and berberine) in commonly used solvents in topical preparations

and to determine oil-water partition coefficient of chrysophanol and berberine in Danhuang gel extract. Method: Dissolvability of Danhuang gel extract and its index components (chrysophanol and berberine) were determined by precipitation method and dissolvability method

oil-water partition coefficient of chrysophanol and berberine were determined by shaking flask method. Result: Danhuang gel extract

chrysophanol and berberine had optimum solubility in propylene glycol

solubility of them were 8.25

60.17

353.01 mg ·L-1;Oil-water partition coefficients of chrysophanol and berberine in Danhuang gel extract were affected by pH. Conclusion: Danhuang gel extract and its index components could be better dissolved in propylene glycol and ethanol;Chrysophanol and berberine had certain fat-soluble and water-soluble in suitable pH

which was beneficial for transdermal absorption.

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Related Institution

Provincial Key Laboratory of Pharmaceutics in Guizhou Province, State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for Development and Application of Ethnic Medicine and Traditional Chinese Medicine, Ministry of Education, School of Pharmaceutical Sciences, Guizhou Medical University

State Key Laboratory of Functions and Applications of Medicinal Plants, Provincial Key Laboratory of Pharmaceutics in Guizhou Province, Engineering Research Center for Development and Application of Ethnic Medicine and Traditional Chinese Medicine, Ministry of Education, School of Pharmaceutical Sciences, Guizhou Medical University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

Henan Tumor Hospital,the Affiliated Tumor Hospital of Zhenzhou University

Henan Medical College for Staff

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