Determination of Dissolution of Evodiamine Dispersible Tablets and Evodiamine Been Processed by Different Methods

SHENG Rong; CHEN Jia; Song Ying; ZHAO Xue-li

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Determination of Dissolution of Evodiamine Dispersible Tablets and Evodiamine Been Processed by Different Methods

更新时间：2024-01-04

- Determination of Dissolution of Evodiamine Dispersible Tablets and Evodiamine Been Processed by Different Methods
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 24, Pages: 32-34(2012)
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- Published：2012
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SHENG Rong, CHEN Jia, Song Ying, et al. Determination of Dissolution of Evodiamine Dispersible Tablets and Evodiamine Been Processed by Different Methods[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 32-34.
DOI：

SHENG Rong, CHEN Jia, Song Ying, et al. Determination of Dissolution of Evodiamine Dispersible Tablets and Evodiamine Been Processed by Different Methods[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 32-34. DOI：

摘要

目的: 测定吴茱萸碱分散片及吴茱萸碱经不同方法处理后的溶出度。方法: 依据《中华人民共和国药典》2010年版溶出度测定法第二法(浆法)

以1%SDS 900 mL为溶出介质

转速100 r·min-1;制备吴茱萸碱-泊洛沙姆188固体分散体、吴茱萸碱超微粉及吴茱萸碱超微粉-泊洛沙姆188固体分散体

HPLC测定溶出度。结果: 吴茱萸碱分散片45 min溶出度>60%;吴茱萸碱超微粉-泊洛沙姆188固体分散体体外溶出度较好。结论: 建立的吴茱萸碱分散片溶出度测定方法简便、快速

可作为吴茱萸碱分散片的溶出度检测方法;吴茱萸碱几乎不溶于水

超微粉碎联合固体分散体技术能显著提高吴茱萸碱的溶出度。

Abstract

Objective:To determine dissolution of evodiamine dispersible tablets and evodiamine which were processed by different methods. Method: According to the second dissolution method(slurry method) in 2010 edition 'Chinese Pharmacopoeia'

1%SDS solution of 900 mL was used as dissolution medium

rotation speed was 100 r·min-1

HPLC was as quantitative method to determine dissolution

evodiamine-poloxamer 188 solid dispersions

evodiamine ultrafine powder and evodiamine ultrafine powder-poloxamer 188 solid dispersions were prepared. Result: Ddissolution of evodiamine dispersible tablets was more than 60% at 45 min;Dissolution of evodiamine ultrafine-poloxamer 188 solid dispersions was higher than others. Conclusion: This established dissolution determination method of evodiamine dispersible tablets was simple and rapid

which could be as dissolution detection method of evodiamine dispersible tablets;Evodiamine was almost insoluble in water

but ultrafine grinding combined with solid dispersion technology could significantly improve dissolution of it.

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