Studies on Antipyretic and Anti-inflammatory Effects of
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Studies on Antipyretic and Anti-inflammatory Effects of
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 4, Pages: 274-276(2013)
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Published:2013
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YANG Chao-yan, CHEN Yan-fen, TAO Shu-hong, et al. Studies on Antipyretic and Anti-inflammatory Effects of [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 274-276.
DOI:
YANG Chao-yan, CHEN Yan-fen, TAO Shu-hong, et al. Studies on Antipyretic and Anti-inflammatory Effects of [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 274-276.DOI:
Studies on Antipyretic and Anti-inflammatory Effects of
Objective: To explore the antipyretic and anti-inflammatory effects of Tylophora ovata. Method: SD rats were divided into 5 groups randomly:physiological saline group
positive control group
the water extract of T. ovata low-dose group (6 g·kg-1)
middle-dose group (12 g·kg-1) and high-dose group (24 g·kg-1). The fever model with high temperature was established induced by yeast in rats
and the inflammatory model with foot edema was established by carrageenan in rats. The antipyretic and the anti-inflammatory effects of T. ovata were observed
the content of prostaglandin E2(PGE2) in paw tissue were tested by ultraviolet spectrophotometry. Result: Compared with the saline group
the water extract of T. ovata middle-dose group and high-dose group showed significant antipyretic activity in rats with high temperature induced by yeast (P<0.05)
and appeared significant anti-inflammatory activity in rats with foot edema induced by carrageenin (P<0.05). Conclusion: T. ovata had notable effects of antipyretic and anti-inflammatory
the anti-inflammatory mechanism might be related to inhibition of PGE2 biosynthesis.
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