Investigation of Dissolution of Ligustrazine Hydrochloride Cucurbituril Inclusion Compound
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Investigation of Dissolution of Ligustrazine Hydrochloride Cucurbituril Inclusion Compound
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 21, Pages: 40-41(2012)
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Published:2012
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XU Jian, ZHANG Yong-ping, MIAO Yan-yan. Investigation of Dissolution of Ligustrazine Hydrochloride Cucurbituril Inclusion Compound[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 40-41.
DOI:
XU Jian, ZHANG Yong-ping, MIAO Yan-yan. Investigation of Dissolution of Ligustrazine Hydrochloride Cucurbituril Inclusion Compound[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 40-41.DOI:
Investigation of Dissolution of Ligustrazine Hydrochloride Cucurbituril Inclusion Compound
Objective: To investigate disslolution of ligustrazine hydrochloride cucurbituril inclusion compound(LHCIC). Method: With ligustrazine hydrochloride as index
accumulated dissolution rate at different time of LHCIC was determined by UV spectrophotometry. Result: Ligustrazine hydrochloride showed good linear relationship of 2.0-10.0 mg ·L-1
accumulated dissolution rate of LHCIC was 1.33 times that of ligustrazine hydrochloride in 5 min
this was maximum difference of them. Conclusion: LHCIC could improve dissolution of ligustrazine hydrochloride and enhance its bioavailability.