Optimization of Preparation Technology for Gefen Instant Granule by -comprehensive Scoring Method
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Optimization of Preparation Technology for Gefen Instant Granule by -comprehensive Scoring Method
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 19, Pages: 56-59(2012)
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Published:2012
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SHI Jun, LIN Wan-ting, LIAO Hua-wei. Optimization of Preparation Technology for Gefen Instant Granule by -comprehensive Scoring Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 56-59.
DOI:
SHI Jun, LIN Wan-ting, LIAO Hua-wei. Optimization of Preparation Technology for Gefen Instant Granule by -comprehensive Scoring Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 56-59.DOI:
Optimization of Preparation Technology for Gefen Instant Granule by -comprehensive Scoring Method
Objective:To investigate and optimize preparation technology of Gefen instant granule. Method:With dissolution time and the content of total flavonoids of this granule as indexes
ratio of sugar- Pueraria lobata
ratio of baking powder-P. lobata
drying temperature were chosen as investigation factors
preparation technology was optimized by orthogonal test with Z-comprehensive analysis method.Three samples were prepared by optimized technology
and their properties
melting
water content and pasting test were investigated.The content of total flavonoids was determined by aluminum nitrate chromomeric method. Result:The best preparation process was as follows:uniform mixed baking powder 1.2 g
dextrin 1.8 g
sugur 24 g
and P. lobata 33 g sequentially by equal increment method
mixed evenly with about 5 mL hot water (35-40℃)
shaped into lump
placed at environment of 35℃ for 40 min to make its interior with multiple and dense holes
volume expansion and soft texture
squeeze sieved
dried at 60℃ for 40min
arranged granules
and then Gefen instant granule were gained.Prepared 3 batches of samples had uniform size
milky white
color consistency
no absorption of moisture
agglomeration and phenomenon of deliquescence.Melting test qualified
it dissolved completely at about 85℃ in hot water.The moisture content was less than 6.0%
and the content of total flavonoids was 0.327 mg·g-1. Conclusion:This optimized preparation technology was simple
feasible and reproducible
and the content of total flavonoids determination method was suitable for quality control of Gefen instant granule.