Objective: To study the effect and mechanism of Gegen Qinlian decoction on myocardial ischemia reperfusion induced arrhythmia in rats

to provide experimental evidence for clinical application. Method: Healthy SD rats were randomly divided into six groups (n=10

each)

sham operation group (given equal volume distilled water)

model group (given equal volume distilled water)

Wenxin keli group (2.43 g·kg-1)

Gegenqinlian decoction high

medium

low dose (8.64

4.32

2.16 g crude drug·kg-1) groups. Beside the sham operation group

the other groups were performed by liquating anterior interventricular branch of the left desending coronary artery to establish myocardial ischemia reperfusion induced arrhythmia. After different intervention for continuous 7 days

electrocardiogram of lead II was examined

and tissue Na+-K+-ATP enzyme (Na+-K+-ATPase)

Ca2+-ATP enzyme (Ca2+-ATPase) and serum superoxide dismutase (SOD) and malondialdehyde (MDA) were determined. Result: Gegenqinlian decoction could significantly reduce the incidence of arrhythmia

serum MDA and increase serum SOD

also significantly increase Na+-K+-ATPase

Ca2+-ATPase activity (P<0.01 or P<0.05). Conclusion: Gegenqinlian decoction has good anti-arrhythmia effect in the way of increasing enzymes activity and removing oxygen free radicals

to improve arrhythmia and protect the ischemic myocardium.