Objective: To investigate the effect of Compound Qizhu tablet on the expression of tumor necrosis factor -α(TNF-α)

interleukin-4(IL-4)

interleukin-8(IL-8) and Interleukin-10(IL-10) in rats with liver fibrosis. Method: Seventy SD rats were randomly divided into normal group

model group

Qizhu high-dose group(water preparation)

Qizhu low dose group(water preparation)

Qizhu high-dose group(ethanol preparation)

Qizhu low dose group(ethanol preparation)

and colchicine group. All the rats except normal group received 40% CCl4 subcutaneous injection twice a week for 8 weeks

rats was firstly given 40%CCl4(5 mL·kg-1)and 3 mL·kg-1secondly. Rats in both Qizhu high-dose group and small dose group were ig given 16.2

9.72 g·kg-1 Qizhu decoction respectively

while rats in colchicine group were fed with 0.5 mg·kg-1 colchicine. Liver histology and liver and spleen index were observed after the modelling. The expression of TNF-α

IL-4

IL-8 and IL-10 was detected by enzyme linked immune sorbent assay(ELISA). Result: The degree of hepatic fibrosis in all treatment groups was obviously reduced compared with model group. Compared with normal group

the expression of TNF-α

IL-4 and IL-8 in model group was elevated significantly

whereas the expression of IL-10 was decreased(P<0.01). Compared with model group

the expression of TNF-α

IL-4 and IL-8 in treatment groups were decreased significantly

whereas the expression of IL-10 was increased (P<0.01). Conclusion: Compound Qizhu tablet has obvious therapeutic effect on rats with liver fibrosis. The mechanism may be correlated to interfering the disturbance of some cytokines such as TNF-α

IL-4

IL-8 and IL-10.