Objective: To study the therapeutic effect of Chinese tradition medicine recipe with the function of cooling blood to remove toxin in treating severe chronic hepatitis and intervening effect of lipopolysacch aride(LPS) recognition receptors. Method: Fifty-eight cases with chronic severe hepatitis patients were rando mLy divided into control group with 30 cases (basic treatment) and observation group with 28 cases (basic treatment plus Chinese herb with the function of cooling blood to remove toxin). The clinical symptom score

serological change

the rate of clinical efficiency after treatment were observed after four weeks

and the levels of endtoxin

sCD14

TLR4 mRNA were detected. Result: The rate of clinical efficiency of observation group(78.6%) was superior to the control group(66.7%)

there was significantl difference between two groups(P<0.05). The clinical symptoms of two groups were improved to various degrees

liver function was ameliorated

chdinest erase(CHE) increased in observation group and there was a significant difference compared with the control group (P<0.05). There were no difference in the levels of endtoxin

sCD14

TLR4 mRNA before treatment between two groups. The levels of endotoxin

sCD14

TLR4 mRNA decreased in observation group after treatment and there was a difference compared with the control group(P<0.05). Conclusion: Chinese tradition medicine recipe with cooling blood to remove toxin is an effective method in treating chronic severe hepatitis

with a high therapeutic effect

and may intervene LPS recognition receptors.