Effects of Ziyin Dihuang Wan on the Expression of VEGF, aV3 and TF in Rabbit Choroid Tissue

WANG Zhi-gang; HU Chun-ping; CAO Peng; YANG Jie; ZHENG Quan-xi; WANG Wei; SUN Li

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Effects of Ziyin Dihuang Wan on the Expression of VEGF, aV3 and TF in Rabbit Choroid Tissue

更新时间：2024-01-04

- Effects of Ziyin Dihuang Wan on the Expression of VEGF, aV3 and TF in Rabbit Choroid Tissue
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 23, Pages: 160-163(2012)
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- Published：2012
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WANG Zhi-gang, HU Chun-ping, CAO Peng, et al. Effects of Ziyin Dihuang Wan on the Expression of VEGF, aV3 and TF in Rabbit Choroid Tissue[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 160-163.
DOI：

WANG Zhi-gang, HU Chun-ping, CAO Peng, et al. Effects of Ziyin Dihuang Wan on the Expression of VEGF, aV3 and TF in Rabbit Choroid Tissue[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 160-163. DOI：

摘要

目的: 研究滋阴地黄丸对兔脉络膜组织中血管内皮生长因子(VEGF)

整合素(aVβ3)

组织因子(TF)表达的影响。方法: 用激光光凝建立脉络膜新生血管(CNV)动物模型

将动物分为4组

分别为空白对照组、模型对照组、滋阴地黄丸高、低剂量组(39

9.75 g·kg-1)

连续ig 30 d后取右眼球进行免疫组织化学染色

测定脉络膜中VEGF

aVβ3

TF的表达。结果: 模型对照组兔眼脉络膜组织中VEGF

aVβ3

TF均呈强阳性表达

滋阴地黄丸低、高剂量组中VEGF

aVβ3

TF则呈弱阳性或阴性表达。与模型组比较

滋阴地黄丸低剂量组明显抑制兔脉络膜中VEFG的表达(P<0.05)

显著地抑制了aVβ3和TF的表达(P<0.01)

滋阴地黄丸高剂量组也显著地抑制了VEGF

aVβ3和TF的表达(P<0.01)。结论: 滋阴地黄丸通过抑制脉络膜中VEGF

aVβ3

TF的表达而抑制了CNV的形成。

Abstract

Objective: To study the effects of Ziyin Dihaung Wan on the expression of vascular endothelial growth factor(VEGF)

integrin (aVβ3) and tissue factor (TF) in rabbit choroids tissue. Method: Chorodial neovascularization (CNV) model was induced by laser

and then administrated with 9.75

39 g·kg-1 Ziyin Dihaung Wan for 30 days and then rabbit eyeballs were performed with immunohistochemical stainingfor determination of the expression of VEGF

aVβ3 and TF in choroid. Result: Compared with the strongly positive expression of VEGF

aVβ3 and TF in model group rabbit choroidal tissue

the expression of VEGF and aVβ3 and TF was weakly positive in low

high dose Ziyin Dihaung Wan treatment groups. Ziyin Dihuang Wan at 9.75 g·kg-1 dose inhibited the expression of VEGF

aVβ3 and TF significantly (P<0.05). Ziyin Dihuangwan at 39 g·kg-1 dose inhibited the expression of VEGF

aVβ3 and TF significantly (P<0.01). Conclusion: Ziyin Dihuang Wan inhibited CNV by inhibiting the expression of VEGF

aVβ3 and TF in rabbit choroids tissue.

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Related Author

HU Ting-ting

CAI Xue-ting

WANG Wei

WANG Yue-fei1

TIAN Yan-jun1

XIAO Xiao-hui1

CUI Qing-zhi1

Related Institution

Department of Gynecology of Tianjin Nankai Hospital

1*),LI Li~2,CHEN Wei-heng~2

中国中医科学院骨伤科研究所

Department of Physiology, Harbin Medical University

Department of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University

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