Research on the Anti-anxiety Effects and the Mechanisms of Qinggong Decoction

ZHANG Shi-liang; LI Yue-lan; ZHANG Li-ying; SONG Yu-liang

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Research on the Anti-anxiety Effects and the Mechanisms of Qinggong Decoction

更新时间：2024-01-04

- Research on the Anti-anxiety Effects and the Mechanisms of Qinggong Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 215-217(2012)
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- Published：2012
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ZHANG Shi-liang, LI Yue-lan, ZHANG Li-ying, et al. Research on the Anti-anxiety Effects and the Mechanisms of Qinggong Decoction[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 215-217.
DOI：

ZHANG Shi-liang, LI Yue-lan, ZHANG Li-ying, et al. Research on the Anti-anxiety Effects and the Mechanisms of Qinggong Decoction[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 215-217. DOI：

摘要

目的: 观察清宫汤对高架十字迷宫小鼠行为学及脑神经递质的影响

探讨其抗焦虑作用及机制。方法: 将雄性小鼠随机分为空白对照组(生理盐水)、地西泮对照组(0.001 5 g ·kg-1)、清宫汤高、中、低剂量组(12

3 g ·kg-1)

每组10只。灌胃给药

每天1次

连续10 d后

采用高架十字迷宫焦虑动物模型

观察清宫汤对小鼠行为学的影响

酶联免疫吸附测定法(ELISA)检测小鼠脑神经递质含量。结果: 清宫汤明显提高小鼠在高架十字迷宫装置中的开放臂进入次数比(OE%)和开放臂停留时间比(OT%);与地西泮组比较

清宫汤高剂量组OE%有显著差异(P<0.01)

低剂量组OT%有显著差异(P<0.05)。脑神经递质测试

清宫汤明显降低5-羟色胺(5-HT)

去甲肾上腺素(NE)浓度

其中中剂量组5-HT浓度降低显著(P<0.05)

高剂量组NE浓度降低显著(P<0.01);与地西泮组比较

清宫汤各组5-HT

NE浓度无显著差异;多巴胺(DA)浓度各组无统计学差异。结论: 清宫汤具有抗焦虑作用

其作用机制与降低小鼠脑组织中5-HT

NE浓度相关。

Abstract

Objective: To investigate the influence of Qinggong decoction(QGD)on behavior and neurotransmitter in the elevated plus-maze mice

and to explore the anti-anxiety effects and the mechanisms. Method: Fifty male mice were randomly divided into 5 groups: control group (normal saline)

diazepam group (0.001 5 g·kg-1)

QGD high-dose group (12 g·kg-1)

medium-dose group (6 g·kg-1) and low- dose group (3 g·kg-1)

and gavage administration was carried out once per day for continuous 10 days. Then adopted anxiety animal model with the elevated plus-maze was used to observe the influence of QGD on behavior

and the concentration of brain neurotransmitter was detected in mice by ELISA. Result: QGD could increase the percentage of the times entering the open arms (OE%) and stay duration in the total period (OT%); compared with diazepam group

the high-dose group had a significant difference in OE%

and low-dose group had a significant difference in OT%. In the neurotransmitter testing

QGD significantly lowered the concentration of 5-hydroxytryptamine(5-HT) and noradrenaline(NE)

and in which medium-dose group significantly reduced the concentration of 5-HT(P < 0.05)

and high-dose group reduced significantly concentration of NE (P < 0.01); compared with diazepam group

the concentration of 5-HT and NE of QGD groups had no obvious difference; the concentration of dopamine(DA) was not statistically different in groups. Conclusion: QGD has anti-anxiety effect

and the mechanism is related to lowering the concentration of 5-HT and NE in mice brain tissues.

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Related Institution

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Engineering Research Center of Chinese Medicine Protection Technology and New Product Development， Ministry of Education， Hubei University of Chinese Medicine

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