Amlodipine and Atorvastatin Combined with Shuxin Jianzhi Tablets for Treatment of Hypertension with Dyslipidemia
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Amlodipine and Atorvastatin Combined with Shuxin Jianzhi Tablets for Treatment of Hypertension with Dyslipidemia
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 22, Pages: 309-311(2012)
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Published:2012
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LI Yuan-zhou, CHEN Ai-wen, ZHENG Ru-yi. Amlodipine and Atorvastatin Combined with Shuxin Jianzhi Tablets for Treatment of Hypertension with Dyslipidemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 309-311.
DOI:
LI Yuan-zhou, CHEN Ai-wen, ZHENG Ru-yi. Amlodipine and Atorvastatin Combined with Shuxin Jianzhi Tablets for Treatment of Hypertension with Dyslipidemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 309-311.DOI:
Amlodipine and Atorvastatin Combined with Shuxin Jianzhi Tablets for Treatment of Hypertension with Dyslipidemia
Objective:To investigate the clinical efficacy of amlodipine and atorvastatin combined with Shuxin Jianzhi tables on treatment of hypertension with dyslipidemia. Method: One hundred and ten hypertensive patients with abnormal lipid were randomly divided into two groups
58 in the control group and 57 in the treatment group
All patients were experienced a two-week washout period
the control group was given with Shuxin Jianzhi tables
4 tablets/time
tid; the treatment group was given amlodipine and atorvastatin(Duodayi
5 mg∶10 mg)once daily for 24 weeks. Changes in blood lipids
blood pressure and cardiovascular adverse event before and after treatment were observed. Result: The blood pressure in the treatment group was more efficient compared with that in the control group (P<0.05). The level of total cholesterol (TC)
triglyceride (TG)
low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) were significant improved in the two groups
the treatment group's improvement was better than that in the control group(P<0.05); The adverse event rate in the treatment group was 8.77%
and that in the control group was 18.86%. Conclusion: Amlodipine and atorvastatin combined with Shuxin Jianzhi tablets was an effective and safe medication program. It can effectively control blood pressure with hypertension and dyslipidemia
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