Pharmacokinetics of Bufadienolide in Shayao Chansu Pill
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Pharmacokinetics of Bufadienolide in Shayao Chansu Pill
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 23, Pages: 156-159(2012)
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Published:2012
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JIA He-li, JI Cheng, GUO Wan-zhou. Pharmacokinetics of Bufadienolide in Shayao Chansu Pill[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 156-159.
DOI:
JIA He-li, JI Cheng, GUO Wan-zhou. Pharmacokinetics of Bufadienolide in Shayao Chansu Pill[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 156-159.DOI:
Pharmacokinetics of Bufadienolide in Shayao Chansu Pill
Objective: To study pharmacokinetics of bufadienolide in Shayao Chansu pill in beagle dogs. Method: Plasma metabolic fingerprint in Beagle dogs was established with UPLC/MS-TOF. The total ion chromatograms in blank plasma
plasma containing control products and plasma obtained from dogs taken Shayao Chansu pill were determined. The plasma containing bufadienolide was methodologically validated and pharmacokinetic study was carried out. Result: The UPLC/MS-TOF method for determining bufadienolide in the Beagle plasma was established
and successfully applied to the pharmacokinetic studies for Beagle plasma after administration of Shayao Chansu pill. Conclusion: The studies provided chemical evidence for safety evaluation of Shayao Chansu pill and references for clinical application of the pill.
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