Objective:To study the effects of extracts from T. triquetrum on blood glucose and blood lipid and insulin(INS) in diabetic mice induced by streptozotocin. Method: T. triquetrum was extracted and separated by reflux extraction with different solvent

petroleum ether fraction

chloroform fraction

ethyl acetate fraction

n-butanol fraction and 60% ethanol fraction were obtained respectively.Type 2 diabete mice models were established by intraperitoneal injection of streptozotocin (STZ)150 mg·kg-1.The experimental mice were randomly divided into eight groups

control group

model group

metformin group(100 mg·kg-1)

petroleum ether group

chloroform group

ethyl acetate group

n-butanol group and 60% ethanol group

the dose were 200 mg·kg-1. Control group and model group were given normal saline. After the experimental mice were administrated with drugs for 20 days

the fasting blood glucose was determined by method of glucose oxidase

fasting insulin was determined by the radioimmunoassay

and blood lipid were determined by chemical method. Result: Compared to model group

ethyl acetate fraction

n-butanol fraction and 60% ethanol fraction could significantly reduce fasting blood glucose level in diabetic mice induced by STZ(P<0.05 or P<0.01). Of all the fractions

60% ethanol parts had the most significant hypoglycemic effect. hypoglycemic rate was 23.61%.It also decreased insulin resistance index (IR)

contents of TG

TC and LDL-C and increased the insulin sensitivity index (ISI) and HDL-C content in the serum significantly (P<0.05 or P<0.01). Chloroform fraction and petroleum ether fraction had no significant effect on diabetic mice(P>0.05). Conclusion: The effective constituent of antidiabetics from Tadehagi triquetrum are mainly exist in the n-butanol fraction and 60% ethanol fraction

they can significantly reduce fasting blood glucose level in diabetic mice induced by STZ

improve insulin resistance and adjust metabolic disturbance.