Objective: In order to investigate the effects of Xianti JiangzhiⅠPrescription in proventing obeseing induced by ovariectory in ratsand explore the possible mechanism. Method: Seventy female SD rats

weighting about 270 g were randomly divided into 7 groups:sham-operated group (sham)

simple ovariectomized group and three treated groups with low(3.3 g · kg-1 · d-1)

middle(6.6 g · kg-1 · d-1) and high(13.2 g · kg-1 · d-1) dosage of Xianti JiangzhiⅠprescription

diethyllstillbestrol group(2.2×10-5g · kg-1 · d-1)

trimetazidine group(8.9×10-4g · kg-1 · d-1)

ten each group. The administration started 10 days after operation and continued for 3 weeks. In the end

the blood samples were collected to measure following indexes:serum estradiol (E2)

blood lipids

leptin

wet weight of fat

et al. Result: Xianti JiangzhiⅠprescription can significantly inhibit the increase of weight and food intake in the model rats(P<0.05 or P<0.01)

decreased the weight of wet abdominal fat

reduce the lees indexes(P<0.05 or P<0.01)

significantly prevented obesity induced by ovariectory

significantly decreased the TG

TC

LDL-C level(P<0.05 or P<0.01)and increased the level of blood estrogen(P<0.05 or P<0.01). Conclusion: Xianti JiangzhiⅠprescription can significantly prevent obesity induced by ovariectory by;decreasing the blood lipids and increasing the level of blood Estrogen

this may be one of its mechanisms.