Optimization of Extraction Process of Volatile Oil from Guanxinkang Capsule by Central Composite Design-Response Surface Methodology

SHI Ming-yi; LI Jian-li; XIE Yan; YANG Shan; XI Jian; WANG Li-jie

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Optimization of Extraction Process of Volatile Oil from Guanxinkang Capsule by Central Composite Design-Response Surface Methodology

更新时间：2024-01-04

- Optimization of Extraction Process of Volatile Oil from Guanxinkang Capsule by Central Composite Design-Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 19, Pages: 47-50(2012)
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- Published：2012
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SHI Ming-yi, LI Jian-li, XIE Yan, et al. Optimization of Extraction Process of Volatile Oil from Guanxinkang Capsule by Central Composite Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 47-50.
DOI：

SHI Ming-yi, LI Jian-li, XIE Yan, et al. Optimization of Extraction Process of Volatile Oil from Guanxinkang Capsule by Central Composite Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 47-50. DOI：

摘要

目的:优选冠心康胶囊中川芎、当归和桂枝挥发油的提取工艺条件。方法:采用水蒸气蒸馏法提取川芎、当归及桂枝中挥发油

以挥发油收率为评价指标

采用星点设计考察加水量、浸泡时间及提取时间对提取工艺的影响

对试验数据进行多元线性回归和二项式拟合

效应面法优选工艺条件

并进行预测分析。结果:由复相关系数可知

指标二项式拟合方程优于多元线性回归方程

确定最佳工艺条件为加9倍量水浸泡80min

蒸馏提取7.5h

提取量预测值与理论值偏差<3%。结论:该优选工艺简便、预测性良好

为冠心康胶囊的工业生产提供试验依据。

Abstract

Objective:To optimize extraction technology conditions of volatile oil from Ligusticum chuanxiong

Angelica sinensis and Cinnamomum cassia in Guanxinkang capsule. Method:Volatile oil from L. chuanxiong

A. sinensis and C. cassia were extracted by steam distillation method

with yield of volatile oil as evaluation index

the amount of water

soaking time and extraction time were investigated by central composite design

test data was fitted by multi-linear equation and second-order polynomial equation

extraction technology conditions were optimized by response surface method

and to predictive analysis. Result:Multiple correlation coefficients from second-order polynomial equation were prior to those from multi-linear equation

optimum extraction process conditions were as follows:soaked 80 min with 9 times the amount of water

distillation time 7.5 h

deviation between observed and predicted values was less than 3%. Conclusion:This optimized process was simple with high predictability

it could provide test basis for industrial production of Guanxinkang capsule.

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Related Author

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Related Institution

State Key Laboratory of Southwestern Chinese Medicine Resources， Chengdu University of Traditional Chinese Medicine

College of Pharmacy， Heilongjiang University of Chinese Medicine

Basic Medical College， Heilongjiang University of Chinese Medicine

Hubei Research Center of Chinese Materia Medica Processing Engineering and Technology， School of Pharmacy，Hubei University of Chinese Medicine

National Engineering Laboratory for Quality Control Technology of Chinese Materia Medica， Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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