Effect of Kangxin Decoction on Regulating Vitamin D in Rats with Myocardial Hypertrophy Induced by Isoproterenol
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Effect of Kangxin Decoction on Regulating Vitamin D in Rats with Myocardial Hypertrophy Induced by Isoproterenol
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 19, Pages: 257-260(2012)
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Published:2012
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CHEN Yun-zhi, YANG Chang-fu, GUO Jun, et al. Effect of Kangxin Decoction on Regulating Vitamin D in Rats with Myocardial Hypertrophy Induced by Isoproterenol[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 257-260.
DOI:
CHEN Yun-zhi, YANG Chang-fu, GUO Jun, et al. Effect of Kangxin Decoction on Regulating Vitamin D in Rats with Myocardial Hypertrophy Induced by Isoproterenol[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 257-260.DOI:
Effect of Kangxin Decoction on Regulating Vitamin D in Rats with Myocardial Hypertrophy Induced by Isoproterenol
Objective:To observe the effect of Kangxin decoction on regulating vitamin D in rats with myocardial hypertrophy induced by isoproterenol. Method:Fifty male SD rats were randomly divided into 5 groups:normal group
model group
three dose groups of Kangxin decoction (10
5
2.5 g·kg-1). Myocardial hypertrophy model in rats was induced by subcutaneous injection of isoproterenol (ISO
2.4 mg·kg-1
7 d). After Kangxin Decoction intervention for 6 weeks
serum 25(OH) D3
atrial natriuretic peptide (ANP)
renin were detected by ELISA. Pathological changes in myocardial tissue were determined by hematoxylin-eosin (HE) staining. Result:Compared with the controls
serum 25(OH) D3 in the model group was reduced
and serum ANP and renin were elevated (P<0.05).Myocardium derangement and fibrotic hyperplasia were also seen in the models. After Kangxin decoction treatment
serum 25(OH) D3 was increased
accompanied with lower ANP and rennin. The degree of myocardial fibrosis was improved after the treatment. Conclusion:Kangxin decoction had an effective role to treat myocardial hypertrophy induced by ISO by regulationg vitamin D and protecting myocardial cells from injury.