Objective:Through screening and analyzing of clinical research literature on vascular cagnitive impairment(VCI)

objectively evaluate the efficacy and the safety of the therapy of invigorating kidney

removing phlegm and blood stasis

to provide clinical evidence of evidence-based medicine. Method: With the method of cochrane systematic review

searching randomized controlled trial(RCT) reports of PubMed

Cochrane

CBM

CNKI

VIP

Wanfang (2001-2011)

collecting the researches met inclusion criteria by two independent evaluators

analyzing data using Revman 5.1. Result: According to the inclusion criteria

screened out 18 articles of RCT qualified reports from 569 of Chinese medicine treatment of VCI

of which 18 reports had relative high quality. The results showed that: ①The therapy of invigorating kidney and removing phlegm and blood stasis had a better efficacy than the control group by mini-mental state examination(MMSE)

BBS(P＜0.05);②There was no significant difference shown by ADL;③ There was no statistical significant difference in safety

indicating that the two groups of incidence of adverse reaction no significant differences by Chi-square test. Conclusion: Available evidences manifests: the therapy has a better efficacy and no significant differences in safety. Due to defects of experimental design and selection of the outcome indexes

should have the process of syndrome differentiation of traditional Chinese medicine(TCM) and make and use unified syndrome curative effect evaluation standard according to syndrome differentiation of TCM

and need to push in more the rational design

the execution strictly

the multi-central and large sample

long time follow-up and has Chinese medicine characteristics double-blind RCT.