Preparation and Quality Control of  Dispersible Tablets

JIA Li-juan; WU Shui-jin; WANG Han; SHEN Yao; JI Yan-yan; WANG Zhong-yan

您当前的位置：

首页 >

文章列表页 >

Preparation and Quality Control of Dispersible Tablets

更新时间：2024-01-04

- Preparation and Quality Control of Dispersible Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 23, Pages: 49-52(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
JIA Li-juan, WU Shui-jin, WANG Han, et al. Preparation and Quality Control of Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 49-52.
DOI：

JIA Li-juan, WU Shui-jin, WANG Han, et al. Preparation and Quality Control of Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 49-52. DOI：

摘要

目的: 采用正交试验筛选金莲花分散片的处方和制备工艺。方法: 以微晶纤维素(A)、低取代羟丙基纤维素(B)、交联聚维酮(C)及微粉硅胶(D)的用量为考察因素

以崩解时限为评价指标

进行正交试验

确定最佳处方;用HPLC对分散片进行质量控制。结果: 当加入30%A

5%B

8%C及8%D 制备的金莲花分散片剂外观光洁、口感良好、平均崩解时间为80 s

分散均匀性符合规定。分散片含荭草苷的量为16.02 mg/片

15 min溶出量达到90%以上。结论: 按优选处方和工艺制得的金莲花分散片

具有一定硬度

遇水迅速崩解并均匀分散

质量可控

满足速释的要求。

Abstract

Objective: To optimize the formulation and process development of Trollius chinensis dispersible tablets. Method: With the amount of microcrystalline cellulose (A)

low replace hydroxypropyl cellulose (B)

crosslinking povidone (C) and aerosol(D) as the influencing factors and the disintegrating time taken as index

the formula of Trollius chinensis dispersible tablets was optimized by orthogonal experiment; the content determination was done by HPLC. Result: The optimized formula was A3B2C3D3.The contents of A

C and D were 30%

8% and 8%

respectively. The products formulated by the optimum techniques were bright and clean

the average disintegration time was 80 s with good distribution homogeneity. The content of orientin was 16.02 mg/piece and the dissolution quantity achieved 90% above in 15 min. Conclusion: The dispersible tablets prepared in this study are better and have a good distribution homogeneity

it can reach the design standard.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on Dynamic Changes of Three Flavonoid C-Glycosides Constituents in Different Harvest Time of Trollius Chninesis

The Fingerprint Studies on Xueshuantong Injection

Studies On Softening and Cutting Process of Phellodendron chinense Schneid.

optimization study on extraction technology of runfei zhike tablets by orthogonal designwith multi-targets

Study on HPLC Fingerprint of Lvjiao Buxue Granules

Related Author

ZHAO Quan-cheng

HE fan

YU Miao

HE Yu-fang

SI Xue-ling

ZHAO Yu-wei

NAN Min-lun

SUN Wei2

Related Institution

Pharmacy Department,Hebei North University

Liaoning University of Traditional Chinese Medicine

Shenyang Institute for Drug Control

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰