Studies on HPLC Fingerprint of Shuangshan Granules

CHEN Yong; XIE Zhen; WEI Tao; ZHENG Xi-ren; ZHANG Long; ZHOU Yuan

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Studies on HPLC Fingerprint of Shuangshan Granules

更新时间：2024-01-04

- Studies on HPLC Fingerprint of Shuangshan Granules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 24, Pages: 110-112(2012)
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- Published：2012
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CHEN Yong, XIE Zhen, WEI Tao, et al. Studies on HPLC Fingerprint of Shuangshan Granules[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 110-112.
DOI：

CHEN Yong, XIE Zhen, WEI Tao, et al. Studies on HPLC Fingerprint of Shuangshan Granules[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 110-112. DOI：

摘要

目的: 建立双山颗粒HPLC指纹图谱分析方法

科学评价并有效控制双山颗粒剂质量。方法: 采用反相高效液相色谱法

色谱柱为Diamonsil C18柱 (4.6 mm×250 mm

5 μm)

乙腈-0.1%磷酸溶液梯度洗脱

流速1.0 mL·min-1

检测波长340 nm

柱温25 ℃。结果: 以绿原酸为参照峰

建立了双山颗粒剂HPLC指纹图谱

确立了13个共有峰

供试品之间的共有峰相似度>0.98。结论: 该方法准确

精密度、重复性较好

可作为控制双山颗粒质量的依据。

Abstract

Objective:HPLC chromatographic fingerprints for Shuangshan granules were developed in order to evaluate the internal quality. Method: HPLC analysis was performed at 25 ℃ by using a Diamonsil C18 column (4.6 mm×250 mm

5 μm)

with the gradient elute of mobile phase consisting of acetonitrile-0.1% glacial acetic acid at the flow rate of 1.0 mL·min-1. The UV detection was set at 340 nm. Result: Chlorogenic acid was used as the reference substance in the HPLC chromatographic fingerprint of Shuangshan Granules

which showed 13 common peaks and the similarity was 0.98 among 10 samples. Conclusion: This method was accurate

repeatable and useful for the quality control of Shuangshan granules.

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Related Institution

School of Pharmacy，Engineering Technology Laboratory for Traditional Chinese Medicine（TCM） Processing and Pharmaceutical Preparation，Supramolecular Mechanism and Mathematic-physics Chracterization for Chinese Materia Medica，Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM，Property and Pharmacodaynamic Key Laboratory of TCM， National Administration of TCM，Hunan University of Chinese Medicine

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National Engineering Research Center for Manufacturing Technology of Solid Preparation of Traditional Chinese Medicine，Jiangxi University of Chinese Medicine

School of Pharmacy， Jiangxi University of Chinese Medicine

Institute of Traditional Chinese Medicine（TCM），Shanghai University of TCM

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