Determination of Equilibrium Solubility and Apparent Oil-water Partition Coefficient of Matrine by HPLC
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Determination of Equilibrium Solubility and Apparent Oil-water Partition Coefficient of Matrine by HPLC
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 20, Pages: 43-45(2012)
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Published:2012
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LIU Bing, LV Jia. Determination of Equilibrium Solubility and Apparent Oil-water Partition Coefficient of Matrine by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 43-45.
DOI:
LIU Bing, LV Jia. Determination of Equilibrium Solubility and Apparent Oil-water Partition Coefficient of Matrine by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 43-45.DOI:
Determination of Equilibrium Solubility and Apparent Oil-water Partition Coefficient of Matrine by HPLC
Objective:To investigate equilibrium solubility and apparent oil-water partition coefficient of matrine at different pH values
and provide basis for development design of matrine liver targeting preparation. Method: Equilibrium solubility and apparent oil-water partition coefficient of matrine at pH 2~11 phosphate buffer were determined respectively
apparent solubility was determined by saturated solution method and shake-flask method
oil-water partition coefficient was calculated through mass concentration ratio of oil phase and water phase after balanced of matrine distribution
the concentration of sample liquid was determined by HPLC. Result: Matrine could dissolve in different pH solution
oil-water partition coefficient had tendency to increase with increasing of pH
it increased significantly in organic solvent
and solubility increased with polarity increasing.Solubility in water 70.26 g·L-1
oil-water partition coefficient of matrxine (lgPapp) was greater than 1.0 when pH>7.00
it could be easy to drug absorption. Conclusion: Matrine had hydrophilic and lipophilic
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Related Institution
Beijing Key Laboratory of Traditional Chinese Medicine(TCM) Quality Evaluation, Beijing University of Chinese Medicine
School of TCM, Beijing University of Chinese Medicine
National Institutes for Food and Drug Control
National Engineering Laboratory for Quality Control Technology of Chinese Materia Medica, Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences