Objective:To explore effect and its mechanism of Didang decoction on chronic prostatitis. Method: Fifty rats were randomly divided into control group (distilled water 10 mL·kg-1)

model group (distilled water 10 mL·kg-1)

Didang decoction high-dose group (16.2 g·kg-1)

low-dose group (8.1 g·kg-1)

positive control group (Qianliekang 0.5 g·kg-1). Chronic prostatitis model was induced by Xiaozhiling injection 0.1 mL. The corresponding drugs were given. The plasma level of thromboxane B2 (TXB2)

6-keto prostaglandin F1α (6-keto-PGF1α)

the tumor necrosis factor-α(TNF-α) was measured. Prostate tissue was collected to observe prostate tissue gland secretion and lumen

interstitial inflammatory cells and fibrous tissue. Result: Compared with model group

plasma TXB level (819±224)μg·L-1

Didang decoction high-dose group

low-dose group and positive control group (915±195)

(1 068±64)

(1 101±317) μg·L-1

is significantly descreased (P<0.05). Compared with pathological model group 6-keto-PGF1α(576±187)μg·L-1

Didang decoction high-dose group

low-dose group and positive control group (1 071±197)

(838±197)

(911±199) μg·L-1 is significantly increased (P<0.05). Compared with pathological model group T/K(2.89±1.04)

Didang decoction high-dose group

low-dose group and positive control group(0.88±0.23)

(1.34±0.31)

(1.28±0.49) is significantly descreased (P<0.05). Compared with pathological model group TNF-α(410±129)μg·L-1

Didang decoction high-dose group

low-dose group and positive control group(144±35)

(312±69)

(238±84)μg·L-1 is significantly descreased (P<0.05). Pathological results show that Didang decoction high-dose group

prostate gland organization lumen

gland secretion

interstitial inflammatory cells

fibre hyperplasia with lower scores

with significant difference were. Conclusion: Didang decoction can lower TXB2

rise 6-keto-PGF1α level

make T/K ratio greatly reduced

at the same time for chronic prostatitis rats inflammation in the blood of the TNF-α possess the inhibition.