Synthesis And Characterization of Hyaluronic Acid Grafted Octadecyl Polymer

LIU Yan-hua; SUN Jin; WANG Wen-ping; HE Zhong-gui

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Synthesis And Characterization of Hyaluronic Acid Grafted Octadecyl Polymer

更新时间：2024-01-04

- Synthesis And Characterization of Hyaluronic Acid Grafted Octadecyl Polymer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 20, Pages: 49-52(2012)
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- Published：2012
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LIU Yan-hua, SUN Jin, WANG Wen-ping, et al. Synthesis And Characterization of Hyaluronic Acid Grafted Octadecyl Polymer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 49-52.
DOI：

LIU Yan-hua, SUN Jin, WANG Wen-ping, et al. Synthesis And Characterization of Hyaluronic Acid Grafted Octadecyl Polymer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 49-52. DOI：

摘要

目的: 合成并表征透明质酸接枝十八烷基(HA-C18)两亲性聚合物。方法: 通过十八烷胺的氨基与透明质酸的羧基发生酰化反应

制得HA-C18聚合物

采用FTIR鉴定合成的HA-C18聚合物的化学结构

评价HA-C18聚合物的自聚集行为

测定其临界聚集浓度;以可静脉注射辅料Tween 80和Cremophor EL为参比

评价HA-C18聚合物的溶血性。结果: 合成的HA-C18聚合物临界聚集质量浓度10.0 mg·L-1

HA-C18胶束溶血性远远低于Tween 80;Cremophor EL溶血性略低于HA-C18胶束

但差异不明显。结论: HA-C18聚合物是优良的可用于静脉注射的难溶性药物载体材料。

Abstract

Objective:To synthesize and characterize hyaluronic acid grafted octadecyl (HA-C18) amphiphilic polymer. Method: HA-C18 polymer was prepared by acylation reaction with carboxyl group of hyaluronic acid and amine group of octadecyl

chemical structure of(HA-C18 polymer were determined by FTIR analysis.Self-aggregation behavior of HA-C18 polymer was evaluated

and critical aggregation concentration was determined;With intravenous accessories of Tween 80 and Cremophor EL as references

hemolysis of HA-C18 polymer was evaluated. Result: The critical aggregation concentration of HA-C18 copolymer was 10.0 mg·L-1.Hemolysis of HA-C18 micelle was far lower than Tween 80;But hemolysis of Cremophor EL was slightly lower than HA-C18 micelles

but their difference was not obvious. Conclusion: HA-C18 copolymer could be used as a novel injectable drug carrier for poor water soluble drugs.

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