To explore the relations between the P-glycoprotein and the nature of traditional Chinese medicine (TCM)

which will be helpful to a better application of the P-glycoprotein in the study on the nature of TCM. Based on the generalization of the latest progresses of the studies on the relation of the P-glycoprotein and the Meridian-guiding herbs

compatibility relations and detoxification by compatibility

we came up with the thoughts of the nature analysis of TCM by P-glycoprotein. We also analyzed the technical characteristics of the study methods of the relationship between the nature of TCM and the P-glycoprotein

including cell model method

in situ perfusion experiment

gene knock-out animal method

and computer simulation. Since some ingredients in the TCM can affect the activity of the P-glycoprotein

by which the interaction of the TCM in vivo can be illustrated from the angle of the transmembrane protein. By the theoretical and methodical application of the P-glycoprotein

new idears for the study of the theoretical study of the nature of the TCM can be worked out

which is good for the mutual osmosis of subjects and the improvement of the application and the modern research of the traditional theory of TCM.