Objective: The present work was designed to study the effects of Liangxue Huoxue formula on fibrinolytic function and collagen metabolism of intestinal tissue in septic rats. Method: Fifty Wistar rats were divided into control

model and treatment group randomly. Sepsis model was established by cecal ligation and puncture (CLP) in rats. Rats in treatment group were administered orally with Liangxue Huoxue formula liquid extract once daily for 72 hours

while those in control and model group with same amount of distilled water. The survival rate was measured. The concentrations of tissue-type plasminogen activator (t-PA)

plasminogen activator inhibitor-1 (PAI-1)

connective tissue growth factor (CTGF)

fibroblast growth factor-10 (FGF-10)

type Ⅰ collagen and type Ⅲ collagen in intestinal tissue were determined by ELISA method. Result: Liangxue Huoxue formula decreased the mortality to 25%

much lower than that in model group (P<0.05). Compared with control group

the t-PA level was decreased (P<0.01) while the expressions of PAI-1

CTGF

FGF-10

type Ⅰcollagen and type Ⅲ collagen in intestinal tissue were increased (P<0.01) in model group. Liangxue Huoxue formula increased t-PA level (P<0.01) and reduced the expressions of PAI-1

CTGF

FGF-10

type Ⅰcollagen and type Ⅲ collagen in intestinal tissue significantly (P<0.01). Conclusion: The fibrinolytic function and collagen metabolism play an important role in the pathological process of multiple organ dysfunction in sepsis and Liangxue Huoxue formula has therapeutic effect on sepsis model by regulating the fibrinolytic function and collagen metabolism.