Studies on Anti-inflammatory and Antibacterial Activities of Aqueous Extract from
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Studies on Anti-inflammatory and Antibacterial Activities of Aqueous Extract from
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 23, Pages: 248-251(2012)
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Published:2012
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PAN Li-ming, LIN Li, HU Xu-guang. Studies on Anti-inflammatory and Antibacterial Activities of Aqueous Extract from [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 248-251.
DOI:
PAN Li-ming, LIN Li, HU Xu-guang. Studies on Anti-inflammatory and Antibacterial Activities of Aqueous Extract from [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 248-251.DOI:
Studies on Anti-inflammatory and Antibacterial Activities of Aqueous Extract from
Objective: To study the antiphlogistic and antibacterial effect of aqueous extract from Mussaenda pubescens. Method: Mice were divided into 5 groups randomly:normal saline (NS)group
positive group
high dose group
middle dose group and low dose group of aqueous extract from M. pubescens (33.6
16.8
8.4 g·kg-1). After 4 d by ig administration
dimethybenzene-induced mouse ear edema model was used to evaluate the anti-inflammation effect. Rats were divided into 5 groups randomly:normal saline (NS) group
positive group
high dose group
middle dose group and low dose group of aqueous extract from M.pubescens (24
12
6 g·kg-1). Using models of carrageenan-induced paw edema and cotton-peller-induced granuloma
anti-inflammation effect was evaluated. Bacteriostasis effect of aqueous extract from M.pubescens was investigated by the method of bacteriostatic test in vitro. Result: The middle and high dose of the extract could significantly relieve ear-swelling caused by dimethylbenzene (P<0.05).The middle and high dose of the extract could significantly inhibit paw swelling in rats within 2
3 hours (P<0.05).The granuloma quality was significantly reduced by the extract compared with the control group (P<0.05). The aqueous extract had antibacterial effects on Staphylococcus aureus
Escherichia coli
Pneumococcus
Streptococcus
Shigella
and the minimum inhibitory concentration(MIC) was 125
31.3
15.7
62.5
62.5 mg·kg-1
respectively. Conclusion: Aqueous extract from M. pubescens has significant anti-inflammatory and antibacterial effects.