Preparation and Quality Standard of Zhixue Zhentong Powder

QIU Jian-guo; ZHANG Quan-long; WEI Li-li; LI Mao-xing; JIA Zheng-ping; ZHANG Ru-xue; ZHOU Jun; QIU Yi-nong

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Preparation and Quality Standard of Zhixue Zhentong Powder

更新时间：2024-01-04

- Preparation and Quality Standard of Zhixue Zhentong Powder
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 15-19(2012)
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- Published：2012
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QIU Jian-guo, ZHANG Quan-long, WEI Li-li, et al. Preparation and Quality Standard of Zhixue Zhentong Powder[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 15-19.
DOI：

QIU Jian-guo, ZHANG Quan-long, WEI Li-li, et al. Preparation and Quality Standard of Zhixue Zhentong Powder[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 15-19. DOI：

摘要

目的: 制备止血镇痛散并建立其质量控制方法。方法: 独一味水提物经聚酰胺柱去除总黄酮

大孔树脂富集得总环烯醚萜苷

以环烯醚萜苷为原料制备独一味止血镇痛散。以8-O-乙酰山栀子苷甲酯为对照品进行薄层色谱定性鉴别;总环烯醚萜苷含量测定采用一阶导数紫外分光光度法;HPLC测定山栀子苷甲酯和8-O-乙酰山栀子苷甲酯的含量。结果: TLC可较好地鉴别8-O-乙酰山栀子苷甲酯

阴性对照显示无干扰;建立的总环烯醚萜苷含量测定方法

平均加样回收率104.40%

RSD 0.64%;建立的山栀子苷甲酯和8-O-乙酰山栀子苷甲酯的含量测定方法

平均加样回收率分别为94.74%

100.59%

RSD分别为2.27%

1.61%。结论: 止血镇痛散的制备工艺可推广于工业化生产中使用;建立的质控方法准确、可靠

可有效评价止血镇痛散的质量。

Abstract

Objective: To prepare Zhixue Zhentong powder

and establish its quality standard to control its therapeutic efficacy. Method: Total flavonoids from water extract of Lamiophlomis rotatawas removed by polyamide column

total iridoid glycoside was enriched by macroporous resin

Zhixue Zhentong powder was prepared with iridoid glycoside as raw material.TLC qualitative identification was adopted with 8-O- acetylshanzhiside methylester as reference substance; The content of total iridoid glycosides was determined by first derivative ultraviolet spectrophotometry;the content of shanzhiside methylester and 8-O- acetylshanzhiside methylester were determined by HPLC. Result: TLC spots of shanzhiside methylester and 8-O- acetylshanzhiside methylester were all clear. Total iridoid glycosides determination for this preparation was established

average recovery of this method was 104.40%

RSD 0.64%. HPLCfor determination of shanzhiside methylester and 8-O- acetylshanzhiside methylester in this preparation was established

average recoveries were 94.74%

100.59%

RSD were 2.27%

1.61%

respectivly. Conclusion: Optimized preparation technology of Zhixue Zhentong powder could be extended for use in industrial production;This established quality control method was accurate and reliable

it could evaluate quality of Zhixue Zhentong powder effectively.

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Related Institution

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