Uniform Design for Optimizing Proportion of Effective Components from and
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Uniform Design for Optimizing Proportion of Effective Components from and
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 19, Pages: 248-251(2012)
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Published:2012
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HE Yan, WEN Fu-chun, JI Feng-lan, et al. Uniform Design for Optimizing Proportion of Effective Components from and[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 248-251.
DOI:
HE Yan, WEN Fu-chun, JI Feng-lan, et al. Uniform Design for Optimizing Proportion of Effective Components from and[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 248-251.DOI:
Uniform Design for Optimizing Proportion of Effective Components from and
Objective:To explore effective way to optimize the proportion of effective components from Panax notoginseng and Crataegus pinnatifida Bge. Method:According to table U6(64) in uniform design
mice were divided into 6 treatment groups
the ratios between flavonoids of Crataeguspinnatifida and total saponins of P. notoginseng were 200:15
100:1.875
50:30
25:3.75
12.5:60
6.25:7.5(mg·kg-1)accordingly. The treatments lasted for 5 days. Then
survival time of mice were evaluated by two models
isoproterenol injection intraperitoneally and acute cerebral ischemia induced by broken neck. The best proportion of effective components was calculated by multiple regression equations. Result:The best ratio appeared to be 20:15 mg·kg-1
namely
the ratio of 4:3.The proportion could prolong the survival time of mice with acute cerebral ischemia (P<0.05). Conclusion:The combination of uniform design and animal models in pharmacodynamics is an effective way to optimize the proportion of Chinese medicinal components.
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