Objective: To observe the clinical efficacy of Zhizhu Kuanzhong capsule in the treatment of functional dyspepsia (FD). Method: Eighty cases reached the standard of FD were randomly divided into treatment group

control group (n=40 each). Patients in two groups were orally given domperidone (10 mg

3 times daily)

and asked to eat easy to digest food

to avoid other drugs with potential influences. The patients in treatment group were orally treated with Zhizhu Kuanzhong capsule (3 tablets

tid). Seven days were considered as a treatment course. After 3 courses of treatment

the outcome was compared for the two groups. Result: The cure rate was 75% in treatment group

and 62.50% in control group

with significant difference (P<0.05). The total efficiency was 95% in treatment group

and 85% in control group

with significant difference (P<0.05). The side effect scores of postoperative nausea and vomiting

loss of appetite

abdominal discomfort

belching

heartburn

acid reflux symptoms in treatmentt group were (0.94 ±0.27)

(0.95±0.44)

(0.75+0.37) points (0.25±0.45)

(0.47±0.12)

(0.76±0.22) accordingly

in the control group they were (1.76±0.32)

(1.51±0.55)

(1.75±0.52)

(1.78±0.41)

(1.45±0.54)

(1.45±0.51) respectively. In two groups

the scores were decreased obviously after the treatment compared with those before the treatment (P<0.05). The treatment group was better than the control group (P<0.05). After treatment

normal slow wave before meals

normal slow wave after meals and the main power ratio before and after meals in the treatment group were (43.62±18.60)%

(52.32±1.54)%

(2.87±2.55)

while in the control group (40.75±15.58)%

(46.32±16.64)%

(2.51±1.23) respectively. In two groups the treatments improved the parameters significantly (P<0.05). The treatment group was better than the control group (P<0.05). Conclusion: Clinical efficacy of Zhizhu Kuanzhong capsule for the treatment of FD is satisfactory.