Objective:To evaluate influence of Qushi Qingre decoction on model of Dampness-heat syndrome. Method: The model of dampness-heat syndrome was induced by multi-factors

including feeding high sugar and high fat food

keeping in an environment

with high temperature and humidity

and infection of rat Salmonella typhi periodically. The effect of Qushi Qingre decoction (3.6

1.8

0.9 g·kg-1

ig 7 d) on dampness-heat syndrome was investigated by whole blood viscosity and the activity of superoside dismutase(SOD) and the malondialdehyde(MDA) in the model rats. Result: Qushi Qingre decoction high dose and middle dose groups could significantly reduce whole blood viscosity (P＜0.01

P<0.05)

and could significantly reduce the concentration of the blood and skin MDA (P＜0.01

P＜0.05). High dose group showed the best effect

of blood viscosity at high

medium

low rates was respectively (2.43±0.22)

(2.88±0.19)

(8.07±0.75) mPa·s

significantly lower than those in the model group (2.92±0.20)

(3.26±0.25)

(9.88±0.63) mPa·s. Qushi Qingre decoction high dose could significantly increase SOD activity in blood and skin (P＜0.01

P＜0.05)

SOD in high-dose group was (6.16±1.12)

(4.05±1.54) U·L-1respectively

significantly higher than that in the model group (2.67±1.04) U·L-1. In the high

medium and low doses groups

the serum MDA (3.78±1.18)

(4.56±0.96)

(7.39±1.79) mmol·L-1 was obviously lower than those in the model group (9.15±1.72) mmol·L-1. The skin MDA levels in the high

medium and low dose groups were (0.65±0.23) (0.84±0.20)

(1.04±0.35) mmol·L-1 respectively

significantly lower than that·L-1] in the model group. Conclusion: Qushi Qingre decoction improves the parameters of the model of damp-heat syndrome significantly.