Effect of 4-methyl-cyclopentadekanone on Learning and Memory in Vascular Dementia Rats
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Effect of 4-methyl-cyclopentadekanone on Learning and Memory in Vascular Dementia Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 20, Pages: 228-230(2012)
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Published:2012
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ZHANG Zi-ran, LIU Ce-jia, BI Li-juan, et al. Effect of 4-methyl-cyclopentadekanone on Learning and Memory in Vascular Dementia Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 228-230.
DOI:
ZHANG Zi-ran, LIU Ce-jia, BI Li-juan, et al. Effect of 4-methyl-cyclopentadekanone on Learning and Memory in Vascular Dementia Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 228-230.DOI:
Effect of 4-methyl-cyclopentadekanone on Learning and Memory in Vascular Dementia Rats
Objective:To evaluate the effect of 4-methyl-cyclopentadekanone on learning and memory in vascular dementia rats. Method: Ninty rats were divided randomly into positive control group(6.1 mg·kg-1)
model group
sham operation group
4-methyl-cyclopentadekanone low
medium and high dose group(8.1
2.7
0.9 mg·kg-1). The model was indueced by arteria carotis ligation
and after 7 days these rats were administrated orally once a day for 28 days and given a administration dose at 10 mL·kg-1.The model group and sham operation group were administrated normal saline. Related biochemical indicators and praxiology in each group were observed. Result: Avoiding dark counts and total cholinesterase(TChE) activity degrade obviously(P<0.05)while the intragastric administration was 8.1
2.7 mg·kg-1
meanwhile the SOD activity increase at a dose of 8.1 mg·kg-1. Conclusion: 4-methyl-cyclopentadekanone can enhance learning and memory in vascular dementia rats.
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