Objective: To establish a new method for on-site rapidly analyzing Qingre Jiedu Oral Solution by near-infrared fibre-optical spectroscopy. Method: The samples are 100 batches of Qingre Jiedu Oral Solution. Baicalin in Qingre Jiedu Oral Solution was examined by HPLC

and then

scaning spectral. Quantitative analysis model of baicalin in Qingre Jiedu Oral Solution was established using partial least squares(PLS).The model conditions was researched

such as different spectral pretreatments and wavelength regression. Result: The correlation coefficients (R2)

the root-mean-square error of estimated(RMSEE) and the RPD of the calibration model for baicalin were 0.915 4

0.040 3 and 3.44

respectively;the root-mean-square error of prediction(RMSEP) and the average rate of recovery were 0.039 9 and 100.299%. Conclusion: The analysis method based on near-infrared fibre-optical spectroscopy provides a foundation for rapid quantitative analysis of Qingre Jiedu Oral Solution

which sets up the foundation of product-line control of Qingre Jiedu Oral Solution and can be used for on-site rapid testing of drugs.