Studies on Chemical Constituents of Effective Fraction of Honeysuckle on Inhibition of  Biofilms

XU Duo-duo; JIANG Xiang-zhi; GAO Yang; ZHENG Wei; HE Min; GAO Qi-pin

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Studies on Chemical Constituents of Effective Fraction of Honeysuckle on Inhibition of Biofilms

更新时间：2024-01-04

- Studies on Chemical Constituents of Effective Fraction of Honeysuckle on Inhibition of Biofilms
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 20, Pages: 122-125(2012)
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- Published：2012
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XU Duo-duo, JIANG Xiang-zhi, GAO Yang, et al. Studies on Chemical Constituents of Effective Fraction of Honeysuckle on Inhibition of Biofilms[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 122-125.
DOI：

XU Duo-duo, JIANG Xiang-zhi, GAO Yang, et al. Studies on Chemical Constituents of Effective Fraction of Honeysuckle on Inhibition of Biofilms[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 122-125. DOI：

摘要

目的: 研究金银花抑制细菌生物膜有效部位中的化学成分。方法: 采用微量板方法对金银花的有效部位进行追踪

并利用硅胶柱色谱等手段分离化学成分

并研究它们对细菌生物膜的影响。结果: 乙醇洗脱部位为有效部位

并分离得到了15个化合物

分别为大豆脑苷Ⅱ( 1 )、5-O-咖啡酰基奎宁酸丁酯( 2 )、白果醇( 3 )、獐牙菜苷( 4 )、7-表断马钱子苷半缩醛内酯( 5 )、十八烷醇( 6 )、二十八烷醇( 7 )、原儿茶醛( 8 )、原儿茶酸( 9 )、肉桂酸( 10 )、咖啡酸( 11 )、熊果酸( 12 )、槲皮素( 13 )、齐墩果酸( 14 )、阿魏酸( 15 )。在质量浓度为1 g·L-1时

化合物 4

12 对大肠埃希菌生物膜的抑制率分别为36.16%

37.16%

46.18%。结论: 化合物 1 首次从金银花中分离到

化合物 4

12 对大肠埃希菌生物膜有一定的抑制作用。

Abstract

Objective:To study the effective fraction and compounds from Honeysuckle on inhibition of bacterial biofilms. Method: The micro-plate method was used as bioassay-guided and compounds were isolated from effective fraction by repeated silica gel column chromatography. Research their effect of bacterial biofilms. Result: The ethanol extract fraction was active site and 15 compounds were obtained from it. Soya-cerebrosideⅡ ( 1 )

5-o-cafffeoyl quinic acid butyl ester ( 2 )

ginnol ( 3 )

sweroside ( 4 )

7-epi-vogeloside ( 5 )

stearyl ( 6 )

octacoylalcohol ( 7 )

protocatechuic aldehyde ( 8 )

protocatechuic ( 9 )

cinnamic acid ( 10 )

caffeic acid ( 11 )

ursolic acid ( 12 )

quercetin ( 13 )

oleanolic acid ( 14 )

ferulic acid ( 15 ). When the concentration was 1 g·L-1

the inhibition rates of compound 4

12 were 36.16%

37.16% and 46.18% separately. Conclusion: Compound 1 isolated from Honeysuckle for the first time. The compound 4

12 had certain inhibition on bacterial biofilms of Escherichia coli biofilms.

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Related Institution

Jangsu Kanion Pharmaceutical Co,Ltd

State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine

Henan University of Traditional Chinese Medicine

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