Study on Release Characteristics of Compound Berberine Hydrochloride Colon Specific Tablets in Rats
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Study on Release Characteristics of Compound Berberine Hydrochloride Colon Specific Tablets in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 19, Pages: 132-136(2012)
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Published:2012
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ZOU Hai-yan, LI Zhao-xia, WANG Yu-rong, et al. Study on Release Characteristics of Compound Berberine Hydrochloride Colon Specific Tablets in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 132-136.
DOI:
ZOU Hai-yan, LI Zhao-xia, WANG Yu-rong, et al. Study on Release Characteristics of Compound Berberine Hydrochloride Colon Specific Tablets in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 132-136.DOI:
Study on Release Characteristics of Compound Berberine Hydrochloride Colon Specific Tablets in Rats
Objective:To evaluate the release characteristics of compound berberine hydrochloride colon specific tablets in rats. Method:The rats were administrated orally with the colon-specific tablets of diameter 3 mm and berberine hydrochloride (BH) suspension respectively. After administration
the rat's plasma and gastrointestinal tissues were collected at different time points within 22 h. The berberine in biosamples was determined by HPLC
using palmatine as internal standard. Drug delivery index (DDI) was calculated. Result:BH in plasma and gastrointestinal tissues showed good linear relationship in the range of 0.02-0.40 mg·L-1 (r>0.998) and 0.05-10.0 mg·L-1 (r>0.999) respectively. The release of BH in tablets mainly distributed in rat's caecum and colon and showed an obvious lag time. The value of Cmaxand AUC0-22 h in rat's colon were 3.1 times and 3.6 times of BH suspension group respectively. The DDI of the tablets was 0.00
0.23
1.17
2.36
8.55 in the rats' gastric
proximal and distal small intestinal
caecal
colonic tissue
respectively. Conclusion:The compound berberine hydrochloride tablet is a carrier for targeting the drug to the colon.
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