Objective: To study the effect of metformin treatment for metabolic syndrome induced by atypical antipsychotic drugs. Method: The patients suffered from metabolic syndrome induced by atypical antipsychotic were randomly divided into the treatment group (hydrochloric acid metformin 500 mg 1 time

daily) and the control group (diet control+exercise). Treatment lasted for 3 months. Before and after treatment the following parameters were observed: height

weight

waist circumference (WAIST)

blood fat

fasting blood sugar (FPG)

blood glucose 2 h after OGTT (PG 2 h)

blood pressure (SBP/DBP)

body mass index (BMI). Result: After the treatment

BMI

WAIST

FPG

PG 2 h

SBP/DBP

serum triglyceride (TG)

high-density lipoprotein (HDL) all were improved significantly (P<0.01). In the control group

after the intervention

only BMI

WAIST

FPG and TG were obviously improved (P<0.05). Except HDL-C

all the other parameters in the treatment group were improved better than those in the control group·m-2vs (0.48±1.18)kg·m-2

(7.53±4.35)cm vs(2.21±5.37)cm

(0.85±0.82)mmol·L-1vs(0.22±0.57)mmol·L-1

(1.31±1.00)mmol·L-1vs(0.21±0.71)mmol·L-1

(0.92±0.55)mmol·L-1vs(0.32±0.65)mmol·L-1

(0.19±0.21)mmol·L-1vs(0.06±0.3)mmol·L-1

(4.59±6.59)mmHg vs(0.76±4.30)mmHg

(4.25±7.03)mmHg vs(0.31±5.63)mmHg

P<0.01]. Conclusion: The interventions in both groups could improve metabolic syndrome caused by atypical antipsychotic drugs

but metformin showed better effects compared with diet control+exercise.