Objective: To study the mechanism of Qilong granula for treating allergic rhinitis (AR). Method: Rats were feeded for one week then randomly divieded into four groups according to male and female: Blank control group

lung qi deficiency of allergic rhinitis model group

Qilong granula group and positive drug Xinqin granula group

(n=15 each). Qilong granula(20 g·kg-1) and Xinqin granula(20 g·kg-1) were treated for two weeks accordingly. The content of interleukin-1(IL-1) and interleukin-4(IL-4) was datermined in serum with immunofluorescence method in each group. Result: The levels of IL-1(127.67±4.58)ng·L-1 and IL-4 (106.87±2.04)ng·L-1 in model group were obviously higher than in blank control group(P<0.01). IL-1 (86.95±4.54)ng·L-1

IL-4(74.35±2.63)ng·L-1 in Qilong granula groups and IL-1(104.61±3.85)ng·L-1

IL-4(88.67±2.06)ng·L-1 in Xinqin granula group were lower than those in model group(P<0.01). The levels of Qilong granula groups were obviously lower than Xinqin granula group(P<0.01). Conclusion: Qilong granula could descent the serum IL-1 and IL-4 in allergic rhinitis with lung qi deficiency.This may be one of posible effect on AR with lung qi deficiency.