Objective:To explore the effect of blood-activating and stasis-resolving medicines on type 2 diabetic rats. Method: Type 2 diabetic rats model was established by feeding high calorie-diet and injection of small-dose streptozotocin(STZ).The selected rats were randomly divided into six groups:normal control group

model group

diamicron group and Suxiao Jiuxin pills group

Diao Xinxuekang group

Compound Danshen dripping pills group. Fasting blood glucose was detected during the administration on 0 week

2th week and 4th week.After 4 week’s administration

oral glucose tolerance test

free fatty acid(FFA)

triglyceride(TG)

total cholesterol(TC)

leptin

glycated serum protein fructose ammonia(GSP) were determined

pancreas and liver were examined. Result: After treatment of 4 weeks

the blood suger in each group was as follows::normal control(5.32±0.69)mmol·L-1

model fgroup(20.40±2.75)mmol·L-1; diamicron group(9.18±3.91)mmol·L-1

and Suxiao Jiuxin pills group(10.72±2.60)mmol·L-1

Diao Xinxuekang group(12.09±3.85)mmol·L-1

Compound Danshen dripping pills group(14.76±2.57)mmol·L-1. The TG in each group was as follows: normal control(0.50±0.08)mmol·L-1

model group(1.00±0.20)mmol·L-1;diamicron group(0.80±0.21)mmol·L-1

and Suxiao Jiuxin pills group(0.70±0.24)mmol·L-1

Diao Xinxuekang group(0.72±0.21)mmol·L-1

Compound Danshen dripping pills group(0.81±0.13)mmol·L-1. Adjust lipid metabolism level

reduce the level of atrophy lesion of pancrea and liver. Conclusion: The blood-activating and stasis-resolving medicines have therapeutic effects on type 2 diabetic rats.