Antiallergic Effect of Aqueous Extract from Shuningkang

DONG Yin-mao; ZHANG Hai-di; MENG Hong; ZHANG Ming-ming

您当前的位置：

首页 >

文章列表页 >

Antiallergic Effect of Aqueous Extract from Shuningkang

更新时间：2024-01-04

- Antiallergic Effect of Aqueous Extract from Shuningkang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 19, Pages: 241-243(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
DONG Yin-mao, ZHANG Hai-di, MENG Hong, et al. Antiallergic Effect of Aqueous Extract from Shuningkang[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 241-243.
DOI：

DONG Yin-mao, ZHANG Hai-di, MENG Hong, et al. Antiallergic Effect of Aqueous Extract from Shuningkang[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 241-243. DOI：

摘要

目的:观察舒宁康水提液对肥大细胞脱颗粒及组胺释放的影响

研究其抗过敏作用。方法:以卵蛋白(OVA)为致敏原

在OVA质量浓度为40mg·L-1作用30min条件下

观察舒宁康0.1

10g·L-1在体外对致敏大鼠肥大细胞脱颗粒及其释放组胺量的影响。结果:以色甘酸钠为阳性对照

舒宁康水提液具有明显的抑制肥大细胞脱颗粒作用

模型组、舒宁康水提液高、中、低剂量组及阳性对照组脱颗粒率分别为(47.53±5.57)%

(25.11±2.56)%

(35.71±6.99)%

(47.11±4.26)%

(22.87±6.52)%;舒宁康水提液对组胺的释放亦有显著的抑制作用

与模型组比

舒宁康水提液高、中、低组及阳性对照组的抑制率分别为16.85%

20.06%

6.58%

16.85%。结论:舒宁康水提液有良好的抗过敏作用

为将其开发成抗敏中药提供了实验依据。

Abstract

Objective:To study the antiallergic action of Shuningkang by investigating the effect of aqueous extract from Shuningkang on mast cell degranulation and histamin releasing in vitro by PMC degranulation percentage and histamine releasing assay. Method:OVA was used as allergen. In the concentration of 40 mg·L-1

30 min conditions

the influences of aqueous extract from Shuningkang 0.1

10 g·L-1on sensitized rat mast cell degranulation and histamine release were investigated. Result:The extract of Shuningkang could inhibit rat PMC degranulation and histamine releasing in vitro. PMC degranulation rates in model group

high

middle

low does groups of Shuningkang and Cromoglicate Sodium group were (47.53±5.57)%

(25.11±2.56)%

(35.71±6.99)%

(47.11±4.26)% and(22.87±6.52)% respectively. Shuningkang showed significant inhibition on histamine release

compared with the model group. In the high

middle

low does groups of Shuningkang and Cromoglicate Sodium group

the inhibition rates on histamine release were 16.85%

20.06%

6.58%

16.85%. Conclusion:Shuningkang has certain effect on skin allergies.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mechanism of Yupingfeng Granule on CU Rats Based on IL-23/IL-17 Inflammation Axis

Studies on Degranuation of Rat Peritoneal Mast Cells and RBL-2H3 Cells Caused by Traditional Chinese Medicine Injections

Related Author

Mei-heng ZHANG

Jin-hao ZENG

Feng XU

Ru-kang CHEN

Li PENG

Jing GUO

LI Yong-mei

LIU Jiong

Related Institution

Chengdu University of Traditional Chinese Medicine ( TCM)

Hospital of Chengdu University of TCM

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰