Optimization of Prescription of Tetrahydropalmatine Gel by Orthogonal Design

XU Jian; MIAO Yan-yan; ZHANG Yong-ping

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Optimization of Prescription of Tetrahydropalmatine Gel by Orthogonal Design

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- Optimization of Prescription of Tetrahydropalmatine Gel by Orthogonal Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 20, Pages: 31-33(2012)
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- Published：2012
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XU Jian, MIAO Yan-yan, ZHANG Yong-ping. Optimization of Prescription of Tetrahydropalmatine Gel by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 31-33.
DOI：

XU Jian, MIAO Yan-yan, ZHANG Yong-ping. Optimization of Prescription of Tetrahydropalmatine Gel by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 31-33. DOI：

摘要

目的: 优化延胡索乙素凝胶剂的处方配比。方法: 选取卡波姆、氮酮、丙二醇、甘油的用量为考察因素

以24 h累积渗透量为指标

采用正交设计法优选延胡索乙素凝胶处方

考察凝胶的体外释药性能。结果: 最佳处方为延胡索乙素1%

卡波姆-940 0.5%

氮酮3%

丙二醇15%

甘油10%。结论: 该凝胶剂配方合理

制备工艺简单易行

体外渗透符合零级动力学方程。

Abstract

Objective:To optimize prescription ratio of tetrahydropalmatine gel. Method: With 24 h accumulative permeation amount as index

the amount of carbomer

azone

propylene glycol

glycerine was chosen as investigating factors

prescription of tetrahydropalmatine gel was optimized by orthogonal design

and to examine in vitro drug release property of this gel. Result: Optimum formulation contained 1% tetrahydropalmatine

0.5% carbomer-940

3% azone

15% propylene glycol

10% glycerol. Conclusion: This optimized formulation was reasonable

preparation technology was stable and simple

its in vitro penetration was in line with zero order kinetic equation.

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Related Author

Xinrui ZHANG

Jing YANG

Yao ZHANG

Ailing ZHANG

Hanfeng YUAN

Zhongming CAO

Xiaojian LUO

Feng WANG

Related Institution

National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine， Jiangxi University of Chinese Medicine

Jiangxi Bencao Tiangong Technology Co. Ltd.

Jiangxi Jiangzhong Traditional Chinese Medicine Decoction Pieces Co. Ltd.

Jiangxi Jinfurong Pharmaceutical Co. Ltd.， CSPC Pharmaceutical Group Co. Ltd.

School of Pharmacy, Anhui University of Chinese Medicine

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