Effects of Jiawei Gualou Qumai Tang on Hepatocyte Growth Factor, Insulin-like Growth Factor-1 and Vascular Endothelial Growth Factor in Renal Tissues of Rats with Diabetic Nephropathy

PENG Xiao-jing; ZHU Hong; XU Dao-liang; SUN Feng; LIU Chang-hua; GAO Bo

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Effects of Jiawei Gualou Qumai Tang on Hepatocyte Growth Factor, Insulin-like Growth Factor-1 and Vascular Endothelial Growth Factor in Renal Tissues of Rats with Diabetic Nephropathy

更新时间：2024-01-04

- Effects of Jiawei Gualou Qumai Tang on Hepatocyte Growth Factor, Insulin-like Growth Factor-1 and Vascular Endothelial Growth Factor in Renal Tissues of Rats with Diabetic Nephropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 17, Pages: 215-218(2012)
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- Published：2012
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PENG Xiao-jing, ZHU Hong, XU Dao-liang, et al. Effects of Jiawei Gualou Qumai Tang on Hepatocyte Growth Factor, Insulin-like Growth Factor-1 and Vascular Endothelial Growth Factor in Renal Tissues of Rats with Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 215-218.
DOI：

PENG Xiao-jing, ZHU Hong, XU Dao-liang, et al. Effects of Jiawei Gualou Qumai Tang on Hepatocyte Growth Factor, Insulin-like Growth Factor-1 and Vascular Endothelial Growth Factor in Renal Tissues of Rats with Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 215-218. DOI：

摘要

目的: 探讨加味栝楼瞿麦汤对糖尿病肾病大鼠的干预作用。方法: 采用单侧肾切除STZ诱导制作糖尿病肾病(DN)模型。分为正常对照组、DN模型组、加味栝楼瞿麦汤低、中、高剂量组、阳性药物(卡托普利)组。治疗组从实验开始第4周起

加味栝楼瞿麦汤高、中、低剂量组分别以5.6

2.8

1.4 g·kg-1 ig

卡托普利1.8×10-3g·kg-1 ig

正常组及模型组均给予2.8 mL·kg-1蒸馏水ig

每天1次

连续8周。观察大鼠一般情况

大鼠肾组织肝细胞生长因子(HGF)、胰岛素样生长因子-1(IGF-1)及血管内皮细胞生长因子(VEGF)的变化。结果: DN模型组大鼠肾组织HGF含量(181.29 ±17.50) ng·L-1

IGF-1含量(8 235.2 ±790.0) ng·L-1

VEGF含量(2 421.3 ±348.3) ng·L-1

均高于正常组

差异显著(P<0.01);各治疗组中

加味栝楼瞿麦汤中剂量组HGF含量(144.21 ± 26.363 7) ng·L-1、高、中剂量组IGF-1含量(5 303.1±944.0)

(6 443.1±628.3) ng·L-1

高剂量组VEGF含量(1 547.7±566.1) ng·L-1

卡托普利组大鼠肾组织HGF含量(133.6±31.3) ng·L-1

IGF-1含量(3 804.3±604.4) ng·L-1、VEGF含量(1 482.8±299.6) ng·L-1

均低于DN组

差异有统计学意义(P<0.01)。结论: 加味栝楼瞿麦汤能够通过下调大鼠肾组织HGF

IGF-1

VEGF的含量

取得改善微循环、增加肾脏血氧供应、加快损伤组织的修复和再生的治疗效果。

Abstract

Objective: To explore intervention of Jiawei Gualou Qumai Tang(GLQM)in hepatocyte growth factor

insulin-like growth factor-1 and vascular endothelial growth factor in rats with diabetic nephropathy. Method: Except those in the normal group

all rats of diabetic nephropathy model were established by with unilateral nephrectomy and intraperitoneal injection of streptozotocin(STZ) induced production. Then rats were randomly divided into five groups: the model group

and the four treated groups treated with low dose of GLQM-L

medium dose of GLQM-M

high dose of GLQM-H

positive medicine (Captopril tablets). The treatments were given via gastrogavage every day starting from the 4th week of modeling

groups treated with high

medium and low dose of GLQM were given via gastrogavage to 5.6

2.8

1.4 g·kg-1

positive drugs (Captopril tablets) group were given via gastrogavage to 1.8×10-3 g·kg-1

the normal group and model group were given 2.8 mL·kg-1 distilled water

once a day for 8 weeks. Then observed the signs of rats and the hepatocyte growth factor (HGF)

insulin-like growth factor-1(IGF-1) and vascular endothelial growth factor (VEGF) changes in renal tissue of rats. Result: The HGF

IGF-1 and VEGF in renal tissues of rats with model were higher than the normal group

there were significant difference among the model group and the normal group(P<0.01); the HGF in renal tissues of rats with GLQM-M and IGF-1 in renal tissues of rats with GLQM-H and GLQM-M and VEGF in renal tissues of rats with GLQM-H and HGF and IGF-1 and VEGF in renal tissues of rats with Captopril tablets were lower than the model group

there were significant difference among the treated groups and the model group(P<0.01); the HGF in renal tissues of rats with GLQM-M and VEGF in renal tissues of rats with GLQM-H were same as Captopril tablets group

there were no significant difference among them; the IGF-1 in renal tissues of rats with GLQM-H was lower than the GLQM-M

there was significant difference between two(P<0.01). Conclusion: Jiawei Gualou Qumai Tang could decrease the HGF

IGF-1 and VEGF in renal tissues of rats

improve microcirculation

increase supply of blood oxygen to renal

speed up the repair and regenerate of injury renal tissue.

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