Effects of Fufang Ejiao Jiang Enhances Efficacy and Reduces Toxicity of 5-FU in Hepatoma H22-bearing Mice

LI Min; MA Hong-yu; SHEN Ji-duo; LI Yu-cheng

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Effects of Fufang Ejiao Jiang Enhances Efficacy and Reduces Toxicity of 5-FU in Hepatoma H22-bearing Mice

更新时间：2024-01-04

- Effects of Fufang Ejiao Jiang Enhances Efficacy and Reduces Toxicity of 5-FU in Hepatoma H22-bearing Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 20, Pages: 216-219(2012)
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- Published：2012
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LI Min, MA Hong-yu, SHEN Ji-duo, et al. Effects of Fufang Ejiao Jiang Enhances Efficacy and Reduces Toxicity of 5-FU in Hepatoma H22-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 216-219.
DOI：

LI Min, MA Hong-yu, SHEN Ji-duo, et al. Effects of Fufang Ejiao Jiang Enhances Efficacy and Reduces Toxicity of 5-FU in Hepatoma H22-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 216-219. DOI：

摘要

目的: 探讨复方阿胶浆对5-氟尿嘧啶(5-FU)抗小鼠H22肝癌的增效减毒作用。方法: SPF级昆明种小鼠接种瘤细胞制备H22肝癌小鼠模型

将肝癌小鼠随机分为荷瘤模型组、5-FU对照组(20 mg·kg-1

ip)、5-FU联用复方阿胶浆高、中、低剂量组(3

1.5

0.75 g·kg-1

以阿胶生药量计)。另设正常对照组(n=10)。连续给药7 d后处死动物

检测外周血白细胞计数

计算瘤重、抑瘤率、脾脏指数和胸腺指数。采用淋巴细胞转化实验检测外周血淋巴细胞转化率;采用鸡红细胞吞噬实验检测腹腔巨噬细胞的吞噬功能。结果: 与5-FU对照组相比

高剂量复方阿胶浆联合治疗组小鼠瘤质量明显减轻(P＜0.05)

脾脏指数、胸腺指数以及外周血白细胞计数均显著提高(P＜0.05)。5-FU化疗使荷瘤小鼠淋巴细胞转化率、腹腔巨噬细胞吞噬率和吞噬指数较荷瘤模型组均显著降低(P＜0.01)。复方阿胶浆联合治疗组小鼠淋巴细胞转化率、腹腔巨噬细胞吞噬率和吞噬指数均显著高于5-FU对照组(P＜0.05)

其中高剂量组分别达(35.9±9.2)%

(41.9±6.3)%

(0.74±0.17)。结论: 复方阿胶浆对5-FU抗小鼠H22肝癌具有明显的化疗增效减毒作用。

Abstract

Objective:To study the effects of Fufang Ejiao Jiang (FFEJJ) against 5-fluorouracil (5-FU) chemotherapy in hepatoma H22-hearing mice. Method: The SPF-Kunming mice were used to establish mouse model of hepatoma H22.The mice were randomly divided into 5 groups: tumor model group

5-FU group (20 mg·kg-1

ip)

5-FU combined FFEJJ group. FFEJJ were orally administrated at a daily dose of 3

1.5

0.75 g·kg-1

respectively corresponding to high

middle and low dose. The normal control group was set up and each group had 10 mice. After continuous administration for 7 d

the peripheral white blood cell count (WBC)

tumor weight

inhibition rate

spleen index and thymus index were measured. The peripheral blood lymphocyte transformation rate and the phagocytotic activity of peritoneal macrophages were detected. Result: The high-dose FFEJJ significantly reduced the tumor weight

elevated the spleen index

thymus index and WBC counts compared with 5-FU group (P＜0.05). 5-FU decreased the lymphocyte transformation rate and peritoneal macrophage phagocytosis rate and the phagocytic index(P＜0.01). These index in FFEJJ group were significantly higher than that of 5-FU group (P＜0.05)

and reached to (35.9±9.2)%

(41.9±6.3)%

and (0.74±0.17) in high dose FFEJJ group respectively. Conclusion: The results suggest that FFEJJ could enhance efficacy and reduce toxicity in hepatoma treatment as a supplement of 5-FU.

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