Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis

WANG Yan-mei; KANG Mei-qing; CUI Yan-bing; XING Zhi-xia; WANG Rui-fang

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Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis

更新时间：2024-01-04

- Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 17, Pages: 267-270(2012)
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- Published：2012
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WANG Yan-mei, KANG Mei-qing, CUI Yan-bing, et al. Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 267-270.
DOI：

WANG Yan-mei, KANG Mei-qing, CUI Yan-bing, et al. Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 267-270. DOI：

摘要

目的: 观察葛根芩连五炭汤治疗溃疡性结肠炎的效果及探讨葛根芩连五炭汤对溃疡性结肠炎患者的细胞因子的影响。方法: 将60例患者随机分为治疗组、对照组。分别给予葛根芩连五炭汤口服灌肠

柳氮磺吡啶肠溶片治疗3 g·d-1

分3次服。观察临床疗效

并检测治疗前后患者血清肿瘤坏死因子-α(TNF-α)

白细胞介素-6(IL-6)和白细胞介素-8( IL-8)的含量。结果: 治疗组疗效明显优于对照组(P＜0.05)

治疗组更能显著降低患者血清TNF-α

IL-6 和 IL-8的水平。结论: 葛根芩连五炭汤治疗溃疡性结肠炎疗效显著

可能通过调节溃疡性结肠炎患者细胞因子而达到治疗作用。

Abstract

Objective: To observer the therapeutic effect of Gegen Qinlian Wutan decoction on tumor necrosis factor-α(TNF-α)

interleukin-6(IL-6) and interleukin-8(IL-8) in patients with active ulcerative colitis (UC). Method: Sixty cases with ulcerative colitis were divided into the treatment group and the control randomly. The treatment group was given Gegen Qinlian Wutan decoction by oral administration. The control group was given Sulfasalazine enteric-coated tablets. TNF-α

IL-6 and IL-8 in serum were detected by ELISA for all patients before and after treatment

and compared with 30 healthy volunteers. Result: Creative effects in the treatment was obviously better than in the control group

the difference was significant (P＜0.05). After treatment

compared with the control group

the treatment group had the lower plasma levels of TNF-α

IL-6 and IL-8 (P＜0.05). Conclusion: Gegen Qinlian Wutan decoction has obvious effect on ulcerative colitis. The down regulation of the expressions of TNF-α

IL-6 and IL-8 in serum may be one of the therapeutic mechanism.

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Related Author

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Related Institution

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Fraditional Chinese Medicine Hospital of Zhongmu County,Zhongmu

Department of Gastroenterology,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

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广州中医药大学脾胃研究所

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