Antifebrile Effect of Maxing Shigan Tang on Fever Induced by LPS in Rats

QU Fei; XU Jing; CUI Yan-ru; XU Guo-liang; YU Ri-yue

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Antifebrile Effect of Maxing Shigan Tang on Fever Induced by LPS in Rats

更新时间：2024-09-23

- Antifebrile Effect of Maxing Shigan Tang on Fever Induced by LPS in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 178-181(2012)
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- Published：2012
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QU Fei, XU Jing, CUI Yan-ru, et al. Antifebrile Effect of Maxing Shigan Tang on Fever Induced by LPS in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 178-181.
DOI：

QU Fei, XU Jing, CUI Yan-ru, et al. Antifebrile Effect of Maxing Shigan Tang on Fever Induced by LPS in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 178-181. DOI：

摘要

目的: 建立静脉注射内毒素的大鼠发热模型

观察麻杏石甘汤的解热作用。方法: 大鼠尾静脉注射多个浓度(5

80 μg ·kg-1)的内毒素

观察各组大鼠的体温变化

建立适宜的尾静脉注射脂多糖(LPS)发热模型;将大鼠随机分为空白组

模型组

给药组(低、中、高剂量分别为1.33

4.5

15.2 g ·kg-1)

实验当天灌胃给药后立即造模

观察麻杏石甘汤对该发热模型动物体温变化的影响。结果: 静脉注射内毒素可引起SD大鼠显著升温(P<0.01)

结果表明静脉注射内毒素致SD大鼠发热模型最佳造模剂量为20 μg ·kg-1。灌服低、中、高剂量麻杏石甘汤的大鼠的体温均较模型组明显降低(P<0.05)。比较各组的体温反应指数TRI值

发现各组的解热效应有明显的剂量效应关系。结论: 麻杏石甘汤对静脉注射LPS诱导的大鼠发热模型具有较好的解热作用

且呈剂量依赖性。

Abstract

Objective: Using rat intravenous endotoxin model of fever to observe the antifebrile effect of Maxing Shigan Tang. Method: the effects of Maxing Shigan Tang on body temperature was observed on the fever induced by intravenous injection of lipopolysaccharide(LPS) at the dose 5

80 μg · kg-1

respectively. The rats were randomly divided into blank group

model group

treatment group (low

medium and high dose respectively 1.33

4.5

15.2 g · kg-1)

the model was induced immediately after administration. Result: Intravenous injection of endotoxin could increase body temperature significantly (P<0.01). The results showed that the dose of intravenous injection of endotoxin induced SD rat fever model was 20 μg · kg-1. The body temperature was significantly lower compared with model group after fed with low

medium and high dose of Maxing Shigan Tang (P<0.05). TRI showed a clear dose-response relationship. Conclusion: Maxing Shigan Tang has a better antifebrile effects on the fever induced by intravenous injection of LPS in rats

and show a dose-dependent manner.

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Related Author

YU Ri-yue1

XU Guo-liang2

CUI Yan-ru3

XU Jing2

QU Fei1

LIU Ming-yu

YAO Kai-tao

CAI Hong-bin

Related Institution

Depatment of Pharmacology,Jiangxi University of Traditional Chinese Medicine

江西中医学院现代中药制剂教育部重点实验室

江西中医学院生理学教研室

The Ninth Hospital of Wuhan

CR&WISCO General Hospital

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