Effect of Qingpeng Past on Synovium Angiogenesis in Rats with Adjuvant Arthritis
|更新时间:2024-01-04
|
Effect of Qingpeng Past on Synovium Angiogenesis in Rats with Adjuvant Arthritis
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 238-241(2012)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2012
稿件说明:
移动端阅览
LI Hui-min, LI Bao-li. Effect of Qingpeng Past on Synovium Angiogenesis in Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 238-241.
DOI:
LI Hui-min, LI Bao-li. Effect of Qingpeng Past on Synovium Angiogenesis in Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 238-241.DOI:
Effect of Qingpeng Past on Synovium Angiogenesis in Rats with Adjuvant Arthritis
Objective: To study the effect of the Qingpeng paste on synovium angiogenesis and cartilage destruction in rats with adjuvant arthritis(AA). Method: The rat AA models were induced by injection of Freund’s complete adjuvant. Then modeling rats were randomly divided in model group
the Qingpeng paste high-does group and the Qingpeng paste low-does group. The treatment groups were given Qingpeng paste 1.6
0.4 g·kg-1 on their right-hindlimb for 4 weeks.The expression of vascular endothelial growth factor(VEGF)
hypoxia inducible factor-1α(HIF-1α)
matrix metalloporoteinase-3(MMP-3)
nitric-oxide synthase(iNOS) were observed. HE staining was used to examine the pathology of synovium on joint. Result: Qingpeng paste high-does and low-does significantly decreased the amount of angiogenesis in synovium compared with the left-hindlimb and the control group. Qingpeng paste high-does significantly decreased the expression of VEGF
HIF-1α
iNOS (P<0.05); low-does significantly decreased the expression of VEGF and iNOS(P<0.05)
the expression of HIF-1α did not change significantly compare with the left-hindlimb and the control group
but the expression of HIF-1α was decreased. However
the expression of MMP-3 did not decrease significantly in the two groups. Conclusion: Qingpeng paste can alleviate the synovium angiogenesis and protect joint cartilage in AA rats.
Expression of HIF-1α and VEGF in Airway Remodeling of Asthmatic Rats and Effection by Administrated Shegan Mahuang Tang
Mechanism of Kidney-tonifying and Liver-regulating Cyclical Therapy and Formula in Improving Endometrial Receptivity during "Implantation Window" in Rats with Polycystic Ovary Syndrome via miR-140-5p/VEGF Pathway
Protective Effect of Taohong Siwutang on Cerebral Ischemia-reperfusion Injury Based on A1/A2 Phenotype Transformation of Astrocytes Mediated by JAK2/STAT3 Pathway
Effect of Xiao Xianxiongtang on 5-FU-mediated Myocardial Fibrosis and Protein Expression of HIF-1α/VEGF Signaling Pathway in Mice
Related Author
LIU Xin
ZOU Zhong-lan
MEI Quan-hui
ZHANG Heng-ping
HUANG Yan
LIU Xin1
ZOU Zhong-lan2
MEI Quan-hui3
Related Institution
Chang De city the first people’s hospital
Deapartment Clinical of University of South China
First Affiliated Hospital of University of South China
Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine