Effect of Ligustrazine on Atherosclerosis in Rabbits

WANG Guo-feng; LU Feng; ZHAO Xia; CHEN Dong-mei

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Effect of Ligustrazine on Atherosclerosis in Rabbits

更新时间：2024-01-04

- Effect of Ligustrazine on Atherosclerosis in Rabbits
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 14, Pages: 202-205(2012)
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- Published：2012
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WANG Guo-feng, LU Feng, ZHAO Xia, et al. Effect of Ligustrazine on Atherosclerosis in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 202-205.
DOI：

WANG Guo-feng, LU Feng, ZHAO Xia, et al. Effect of Ligustrazine on Atherosclerosis in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 202-205. DOI：

摘要

目的: 研究川芎嗪抗动脉粥样硬化(AS)的药效学及作用机制。方法: 随机将24只新西兰家兔分为4组

即正常饮食组、模型对照组、川芎嗪(75 mg·kg-1)组及川芎嗪(150 mg·kg-1)组。采用高脂饲料建立AS模型

12周后评价川芎嗪对主动脉斑块面积、内膜/中膜厚度比值、内膜泡沫细胞数、HE染色后主动脉形态学及血脂水平的影响。结果: 川芎嗪(75

150 mg·kg-1)与模型对照组比较

其斑块面积分别为(420.4±46.2)mm2

(310.2±12.3 )mm2

(663.2±38.9)mm2

P<0.01;内膜/中膜厚度比值(0.32±0.06)

(0.24±0.15)

(1.21±0.10)(P<0.01);降低内膜泡沫细胞数分别为(9.8±5.1)个/mm2

(5.3±1.2)个/mm2

(23.6±6.7)个/mm2(P<0.01)。HE染色后的光镜下

川芎嗪可减轻主动脉内膜增厚程度

降低泡沫细胞聚集

保持中膜和平滑肌结构基本完整

减少内皮细胞脱落

改善主动脉紊乱的形态结构;川芎嗪还可降低血脂水平而维持内皮细胞正常的生理功能。结论: 川芎嗪靶向内皮细胞干预AS早期始动环节

抑制泡沫细胞形成产生抗AS作用。

Abstract

Objective: To investigate the antiatherosclerotic efficacy by ligustrazine (LIG). Method: Twenty-four rabbits were randomly divided into four groups: normal control group

model control group

LIG (75 mg·kg-1) group and LIG (150 mg·kg-1) group. In in vivo experiments

rabbits fed by high cholesterol diet have been used to evaluate the antiatherosclerotic efficacy of LIG (75

150 mg·kg-1) including plaque surface area in aorta

intima/media (I/M) ratios

foam cell amounts

serum lipid level of tolal cholesterol(TC)

triglyceride(TG)

low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) after twelve weeks. Result: Comparied with model control group

LIG could reduce the plaque surface area in aorta at the dose of 75

150 mg·kg-1 (420.4±46.2) mm2 and (310.2±12.3) mm2 vs (663.2±38.9) mm2

P<0.01). I/M ratios and foam cell amounts were also decreased (P<0.01). Serum lipid level of TC

TG and LDL-C was depressed; however serum level of HDL-C had no changes. Conclusion: Antiatherosclerotic effects by LIG lie at endothelial cells.

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