Effects of Ziyin Dihuang Wan on Expression of VEGF, bFGF and PEDF in Rabbit Choroid Tissue

HU Ting-ting; CAO Peng; WANG Zhi-gang; HU Chun-ping; YANG Jie; CAI Xue-ting; WANG Wei

您当前的位置：

首页 >

文章列表页 >

Effects of Ziyin Dihuang Wan on Expression of VEGF, bFGF and PEDF in Rabbit Choroid Tissue

更新时间：2024-01-04

- Effects of Ziyin Dihuang Wan on Expression of VEGF, bFGF and PEDF in Rabbit Choroid Tissue
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 14, Pages: 220-223(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
HU Ting-ting, CAO Peng, WANG Zhi-gang, et al. Effects of Ziyin Dihuang Wan on Expression of VEGF, bFGF and PEDF in Rabbit Choroid Tissue[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 220-223.
DOI：

HU Ting-ting, CAO Peng, WANG Zhi-gang, et al. Effects of Ziyin Dihuang Wan on Expression of VEGF, bFGF and PEDF in Rabbit Choroid Tissue[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 220-223. DOI：

摘要

目的: 研究滋阴地黄丸对兔眼脉络膜组织中血管内皮生长因子(VEGF)

色素上皮衍生因子(bFGF)

碱性成纤维细胞生长因子(PEDF)表达的影响。方法: 用激光光凝建立兔眼脉络膜新生血管(CNV)动物模型

ig滋阴地黄丸9.75

39 g·kg-1

连续30 d后取眼球进行免疫组织化学染色

测定脉络膜中VEGF

bFGF及PEDF的表达。结果: 模型对照组兔眼脉络膜组织中VEGF

bFGF呈强阳性表达及PEDF的弱阳性表达

滋阴地黄丸低、高剂量组中VEGF

bFGF的表达呈阳性或弱阳性

PEDF则呈阳性或强阳性表达。滋阴地黄丸低、高剂量兔眼脉络膜VEGF的表达为(1.20±0.45)

(0.40±0.55)分

模型组为(2.60±0.55)分

(P<0.01);低、高剂量组bFGF的表达为(1.40±0.55)

(0.40±0.55)分

模型组为(2.80±0.45)分

(P<0.01)

低、高剂量组PEDF为(1.60±0.89)

(2.80±0.45)分

模型组为(0.40±0.55)分(P<0.05

P<0.01)。滋阴地黄丸显著地抑制VEGF和bFGF的表达

诱导了PEDF的表达。结论: 滋阴地黄丸通过抑制脉络膜中VEGF

bFGF的表达

诱导PEDF的表达而抑制了CNV的形成。

Abstract

Objective: To study the effects of Ziyin Dihaung Wan(ZDW) on the expression of vascular endothelial growth factor (VEGF)

fibroblast growth factor(bFGF)and pigment epitheliumderived factor (PEDF) in rabbit choroids tissue. Method: Chorodial Neovascularization (CNV) model was induced by laser

and then administrated with 9.75

39 g·kg-1 ZDW for 30 days and then rabbit eyeballs were performed immunohistochemical staining in determination of the expression of VEGF

bFGF and PEDF in choroid. Result: Comparing with the strongly positive expression of VEGF

bFGF and weak expression of PEDF in model group rabbit choroidal tissue

the expression of VEGF and bFGF were positive or weakly positive

PEDF expression was positive or strongly positive in low

high dose ZDW treatment groups. Comparing with model control group

ZDW at 9.75 g·kg-1 dose inhibited the expression of VEGF

bFGF significantly (P<0.01) and induced the PEDF significantly (P<0.05). ZDW at 39 g·kg-1 dose inhibited the expression of VEGF

bFGF and induced the expression of PEDF significantly(P<0.01). Conclusion: ZDW inhibited CNV by inhibiting the expression of VEGF and bFGF and inducing the expression of PEDF in rabbit choroids tissue.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Ziyin Dihuang Wan on the Expression of VEGF, aV3 and TF in Rabbit Choroid Tissue

The Effect of Yiqi Tongbi Mixture on Angiogenesis of Synovial Membrane in CIA Rats

Effect of Jianpi Huoxue Decoction on the Expression of Vascular Endothelial Growth Factor in Steroid-induced Osteonecrosis of the Femoral Head

Related Author

ZHENG Quan-xi

WANG Wei

SUN Li

WANG Yue-fei1

TIAN Yan-jun1

XIAO Xiao-hui1

CUI Qing-zhi1

Related Institution

Department of Gynecology of Tianjin Nankai Hospital

1*),LI Li~2,CHEN Wei-heng~2

中国中医科学院骨伤科研究所

Department of Physiology, Harbin Medical University

Department of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰