Objective: The therapeutical effect of Rougan Xiaozhi decoction(RXD) in rats with fatty liver disease was studied. Method: The rat model with fatty liver disease was established by feeding high fat diet for 6 weeks.Then the rats were randomly divided into 6 groups:RXD groups(high dose

middle dose

low dose)

Xuezhikang group

model group and control group.Four weeks later

Liver pathologic changes were observed together with the activity of serum alanine transaminase(ALT)

aspartale transaminase(AST)

the blood lipid

and the content of liver free fatty acids(FFA)

total cholesterol(TG)

low-density lipoprotein cholesterol(LDL-C)

high density lipoprotein cholesterol(HDL-C)

superoxide dismutase(SOD)

malonaldehyde(MDA)

nitric oxide(NO). Result: Compared with the natural model group

the level of ALT[(20.38±7.04)

(29.74±6.77)U·L-1

P<0.05]

AST[(118.37±5.14)

(167.43±15.67)U·L-1

P<0.05]

FFA[(453.12±81.36)

(1 447.62±205.85)μmol·L-1

P<0.05]

TG[(0.47±0.42)

(1.85±1.46)mmol·L-1

P<0.01];LDL-C[(0.33±0.08)

(0.44±0.05) mmol·L-1

P<0.05]

HDL-C[(1.03±0.18)

(0.78±0.16) mmol·L-1

P<0.05] mmol·L-1

SOD[(38.72±1.15)

(30.81±4.52)U·mg-1

P<0.05]

MDA[(2.76±0.25)

(6.51±2.66)nmol·mg-1

P<0.01]

NO[(32.27±2.65)

(83.54±6.21)μmol·L-1

P<0.01]

further more it shows dose-effect relation

the effect of high dose group was correspond with Xuezhikang group;the hepatic steatosis degree were lighten obviously(P<0.01). Conclusion: RXD has a good effect on fatty liver disease.This may lie in decreasing blood lipid and prevention of lipid peroxidation.