Objective:To explore forming prescription and preparation technology of sugar-free Jianpi granule

and verify its rationality and feasibility. Method: Forming prescription and preparation technology of sugar-free Jianpi granule and Jianpi granule were compared

and this two kinds of granule were identified quantitatively and qualitatively by HPLC and TLC. Result: Prepared sugar-free Jianpi granule with lactose and dextrin complied with requirement of 2010 edition 'Chinese Pharmacopoeia’;Atractylodes macrocephala

Citrus reticulata and Citrus aurantium from two kinds of granule could be identified by TLC;The mass fraction of hesperidin from sugar-free Jianpi granule was 10.15 mg·g-1

but hesperidin from Jianpi granule was 10.64 mg·g-1. Conclusion: Sugar-free Jianpi granule could completely replace Jianpi granule

because it had advantages of stable quality

low dosage and large scope of clinical application with removing medication restriction of ban sugar patients.