Determination of Baicalin in Relieving Itching Cream Intermediate Products by HPLC

ZHU Hong; ZHOU Xu; ZHANG Shi-long; ZHOU Yan-ping; LIU Feng-qun

您当前的位置：

首页 >

文章列表页 >

Determination of Baicalin in Relieving Itching Cream Intermediate Products by HPLC

更新时间：2024-01-04

- Determination of Baicalin in Relieving Itching Cream Intermediate Products by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 20, Pages: 106-108(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
ZHU Hong, ZHOU Xu, ZHANG Shi-long, et al. Determination of Baicalin in Relieving Itching Cream Intermediate Products by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 106-108.
DOI：

ZHU Hong, ZHOU Xu, ZHANG Shi-long, et al. Determination of Baicalin in Relieving Itching Cream Intermediate Products by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 106-108. DOI：

摘要

目的: 采用高效液相色谱法测定止痒乳膏中间体中黄芩苷的含量。方法: 采用Eclipse Plus C18 色谱柱

以甲醇-0.37%磷酸为流动相

梯度洗脱

检测波长280 nm

流速1.0 mL·min-1。结果: 黄芩苷在0.0792~0.792 μg线性关系良好(r2=0.999 9)

回收率98.87%

RSD 1.14%(n=6);监测3批止痒乳膏中间体表明:黄芩水提物中黄芩苷的含量分别为5.75

6.08

5.94 g·L-1。结论: 方法稳定、灵敏、准确

能够有效的监控上述中间体的质量

可作为该制剂生产过程中质量控制。

Abstract

Objective:To establish a high performance liquid chromatographic method (HPLC) for determination of baicalin in relieving itching cream intermediate products. Method: Agilent Eclipse Plus C18 column was used to separate the analyte with a mobile phase consisting of methyl alcohol and 0.37% phosphoric acid at a flow rate of 1 mL·min-1. The detection wavelength was set at 280 nm. Result: Baicalin showed good linearity (r2=0.999 9) in the range of the tested concentration (0.0792-0.792 μg); the average recovery of the method was 98.87% with RSD 1.14% (n=6). This method was used to successfully determine 3 batches relieving itching cream intermediate products

the content of baicalin in aqueous extract of Scutellaria Baicalensis was 5.75

6.08

5.94 g·L-1. Conclusion: This is a more stable

sensitive and precise method for monitoring relieving itching cream intermediate products

which could also be used as the quality control method for the process of the relieving itching cream.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Determination of Chlorogenic Acid、Baicalin and Phillyrin in Shuanghuanglian in-situ Gel by HPLC

Determination of Baicalin, Jasminoidin and Paeonolin Qindan Particles by HPLC

Related Author

ZHONG Hua-lin

LI Xiao-hua

CHEN Liang-mian1

WANG Jin-yu1

TONG Yan1

PENG Xin-jun2

MA Zhen-shan1

Related Institution

Nanning institute for Food and Drug Control of Guangxi

China Academy of Chinese Medical Sciences Orthopedics Institute

Pharmacy Department of Daqing Branch of Harbin Medical University

Institute of Traditional Chinese of Jixi

Nanjing Children’s Hospital,Nanjing Medical University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰