Evaluation of Wuwei Jiangya Fang on Its Antihypertensive Effect and Its Blood Exposure Components

ZHAO Bao-sheng; YANG Wen-ning; YU Li; ZHANG Kai-lun; ZHAO Hui-hui; LIU Yang; GAO Xiao-yan; ZHU Yin-di; GUI Hai-shui; LIU Li-ying; CAO Yan-fei; DONG Hong-huan; ZHANG Lei

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Evaluation of Wuwei Jiangya Fang on Its Antihypertensive Effect and Its Blood Exposure Components

更新时间：2024-09-23

- Evaluation of Wuwei Jiangya Fang on Its Antihypertensive Effect and Its Blood Exposure Components
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 258-261(2012)
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- Published：2012
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ZHAO Bao-sheng, YANG Wen-ning, YU Li, et al. Evaluation of Wuwei Jiangya Fang on Its Antihypertensive Effect and Its Blood Exposure Components[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 258-261.
DOI：

ZHAO Bao-sheng, YANG Wen-ning, YU Li, et al. Evaluation of Wuwei Jiangya Fang on Its Antihypertensive Effect and Its Blood Exposure Components[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 258-261. DOI：

摘要

目的: 研究五味降压方对自发性高血压大鼠(SHR)的降压作用

并对五味降压方起效的血中暴露成分进行研究。方法: 五味降压方2.6 g ·kg-1大鼠灌胃给药(相当于人临床日用量的12倍)

每日1次

连续4周

每周测定大鼠血压1次;末次测定血压后

腹主动脉采血

分离血浆

反相高效液相色谱法建立五味降压方以及血中多成分指纹图谱

探明降压疗效反应呈现下的暴露成分。结果: 五味降压方从第2周起表现出明显的降血压作用(P<0.01);对血中多成分指纹图谱进行分析

发现五味降压方在降压疗效发生时

有紫外吸收成分进入血液。结论: 五味降压方药效反应明显

血中可见具有紫外吸收的暴露成分

其暴露成分的确切性质有待于通过化学研究工作进一步阐明。

Abstract

Objective: To study the hypotensive effect of Wuwei Jiangya Fang to spontaneous hypertensive rats(SHR)

and analyze its blood exposure compositions which would be the effective components. Method: Wuwei Jiangya Fang was extracted with water and administrated to the SHR rats per oral

once a day; the dosage was 2.6 g · kg-1 per day. During the period of the experiment

the tail blood pressure was measured every week. SHR rats were anesthetized and the blood was taken from abdominal aorta. We established the fingerprints of Wuwei Jiangya Fang and its serum compounds with RP-HPLC method

and determined the exposed components which showed antihypertensive efficacy. Result: Wuwei Jiangya Fang showed obvious anti-hypertension effect (P<0.01) when the rats were administered for 2 weeks or longer. Through the analysis to blood multiple component fingerprint

we found that when Wuwei Jiangya Fang showed its antihypertensive effect

certain components which had UV absorption were found in the blood. Conclusion: Wuwei Jiangya Fang showed obvious anti-hypertension effect and certain exposure components of it which showed UV absorption were found in the blood. Further chemical research works were needed to clarify the character of the exposure components.

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Related Author

ZHAO Hui-hui1

ZHANG Lei2

DONG Hong-huan2

CAO Yan-fei2

LIU Li-ying2

GUI Hai-shui2

ZHU Yin-di2

GAO Xiao-yan1

Related Institution

Center of Scientific Experiment,Beijing University of Chinese Medicine

School of Chinese Materia Medica,Beijing University of Chinese Medicine

Graduated School of Beijing University of Chinese Medicine

Guangxi Medical University

Guangxi Traditional Chinese Medical University

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